Effect of a Coriolus versicolor-based vaginal gel on cervical epithelialization and vaginal microbiota in HPV-positive women: EPICERVIX pilot study
- Silvia González 2
- Luís Serrano 2
- Javier Cortés 3
- Teresa Vezza 45
- José Garrido-Mesa 5
- Francesca Algieri 5
- Rocío Morón 56
- Maria Elena Rodríguez Cabezas 45
- Julio Gálvez 45
- Alba Rodríguez Nogales 145
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1
Hospital Universitario Virgen de las Nieves
info
- 2 Department of Gynaecology, Policlínico HM Gabinete Velázquez, Madrid, Spain.
- 3 Cytopathology. Oncological Gynaecology, Private Practice, Palma, Spain.
- 4 Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.
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5
Universidad de Granada
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- 6 Department of Hospital Pharmacy. Hospital Universitario Clínico San Cecilio. Granada, Spain.
ISSN: 2255-0560
Ano de publicación: 2022
Volume: 37
Número: 2
Páxinas: 139-145
Tipo: Artigo
Resumo
Objetivos: Un gel vaginal basado en Coriolus versicolor (Papilocare®) ha mostrado acelerar la epitelización de la mucosa cervicovaginal y una tendencia a mejorar la composición de la microbiota en mujeres sanas. El estudio fue diseñado para evaluar los efectos de este gel sobre la mucosa cervicovaginal y la composición de la microbiota de mujeres VPH positivas con citología y colposcopía normales. Métodos: Un total de 21 mujeres fueron tratados una vez al día con Papilocare® durante 21 días. En el momento basal y al final del tratamiento, se evaluó el grado de epitelización de la mucosa cervical mediante colposcopía (y se cuantificó mediante una escala Likert de cinco puntos) y se analizó la composición de la microbiota vaginal mediante tecnologías nuevas de secuenciación. Resultados: Al final del tratamiento, la epitelización de la mucosa cervical mejoró en el 52.6% de las mujeres. El tratamiento produjo una reducción estadísticamente significativa en la diversidad filogenética. Además, se redujo la abundancia de Proteobacteria phylum (38.5% vs 93.6% en el momento basal), mientras que se incrementó la deFirmicutes phylum (44.6% vs 2.1%). Se observó un aumento y disminución significativa de las proporciones de Lactobacillus spp. Beij. (familia Lactobacillaceae), incluyendo L. crispatus and L. iners, y de Gardnerella vaginalis, respectivamente. Conclusiones: La aplicación del gel vaginal basado en Coriolus versicolor mejoró significativamente la epitelización del ectocérvix y la composición de la microbiota vaginal en mujeres VPH positivas sin lesiones cervicales, lo que podría apoyar su uso para prevenir las lesiones de cérvix asociadas al VPH.
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