NEUDOL
NEUROFARMACOLOGIA DEL DOLOR
Publications (14) Publications in which a researcher has participated
2025
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Discovery of (3-Phenylcarbamoyl-3,4-dihydro-2H-pyrrol-2-yl)phosphonates as Imidazoline I2 Receptor Ligands with Anti-Alzheimer and Analgesic Properties
Journal of Medicinal Chemistry, Vol. 68, Núm. 3, pp. 2551-2573
2023
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Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity
Journal of Medicinal Chemistry, Vol. 66, Núm. 16, pp. 11447-11463
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Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands
ACS Chemical Neuroscience, Vol. 14, Núm. 10, pp. 1845-1858
2022
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Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties
ACS Chemical Neuroscience, Vol. 13, Núm. 1, pp. 1-15
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Synthesis of tropane-based σ1 receptor antagonists with antiallodynic activity
European Journal of Medicinal Chemistry, Vol. 230
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Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors
Journal of medicinal chemistry, Vol. 65, Núm. 20, pp. 13660-13680
2021
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Chemoenzymatic synthesis of 2,6-disubstituted tetrahydropyrans with high σ1 receptor affinity, antitumor and analgesic activity
European Journal of Medicinal Chemistry, Vol. 219
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Tricyclic Triazoles as σ1Receptor Antagonists for Treating Pain
Journal of Medicinal Chemistry, Vol. 64, Núm. 8, pp. 5157-5170
2020
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Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists
ACS Medicinal Chemistry Letters, Vol. 11, Núm. 5, pp. 678-685
2019
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Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and σ1 receptor antagonists: Synthesis, receptor affinity, selectivity and antiallodynic activity
European Journal of Medicinal Chemistry, Vol. 177, pp. 47-62
2018
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(+)-Methyl (1 R, 2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] derivatives as potent and selective sigma receptor ligands: Stereochemistry and pharmacological properties
Journal of Medicinal Chemistry, Vol. 61, Núm. 1, pp. 372-384
2017
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(+)-and (−)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ1antagonist properties and antinociceptive effects
European Journal of Medicinal Chemistry, Vol. 125, pp. 603-610
2013
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Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea
Journal of Natural Products, Vol. 76, Núm. 4, pp. 737-740
2011
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Novel potent and selective θ ligands: Evaluation of their agonist and antagonist properties
Journal of Medicinal Chemistry, Vol. 54, Núm. 10, pp. 3669-3673