Publications (32) Publications in which a researcher has participated

filter_list Pharmacology

2025

  1. Development of selective sigma-1 receptor ligands with antiallodynic activity: A focus on piperidine and piperazine scaffolds

    European Journal of Medicinal Chemistry, Vol. 281

  2. Discovery of (3-Phenylcarbamoyl-3,4-dihydro-2H-pyrrol-2-yl)phosphonates as Imidazoline I2 Receptor Ligands with Anti-Alzheimer and Analgesic Properties

    Journal of Medicinal Chemistry, Vol. 68, Núm. 3, pp. 2551-2573

2024

  1. Corrigendum to “Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and male Zücker diabetic fatty rats” [Biomed. Pharmacother. 172 (2024) 116314] (Biomedicine & Pharmacotherapy (2024) 172, (S0753332224001951), (10.1016/j.biopha.2024.116314))

    Biomedicine and Pharmacotherapy

  2. The proof of concept of 2-{3-[N-(1-benzylpiperidin-4-yl)propyl]amino}-6-[N-methyl-N-(prop-2-yn-1-yl)amino]-4-phenylpyridine-3,5-dicarbonitrile for the therapy of neuropathic pain

    Bioorganic Chemistry, Vol. 150

2023

  1. Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity

    Journal of Medicinal Chemistry, Vol. 66, Núm. 16, pp. 11447-11463

  2. Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain

    Journal of Medicinal Chemistry, Vol. 66, Núm. 14, pp. 9658-9683

  3. Investigational Drugs for the Treatment of Postherpetic Neuralgia: Systematic Review of Randomized Controlled Trials

    International Journal of Molecular Sciences, Vol. 24, Núm. 16

  4. Small Synthetic Hyaluronan Disaccharide BIS014 Mitigates Neuropathic Pain in Mice

    Journal of Pain, Vol. 24, Núm. 1, pp. 68-83

2022

  1. Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation

    European Journal of Medicinal Chemistry, Vol. 230

  2. Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties

    ACS Chemical Neuroscience, Vol. 13, Núm. 1, pp. 1-15

  3. Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors

    Journal of medicinal chemistry, Vol. 65, Núm. 20, pp. 13660-13680

2020

  1. Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists

    ACS Medicinal Chemistry Letters, Vol. 11, Núm. 5, pp. 678-685

2019

  1. Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and σ1 receptor antagonists: Synthesis, receptor affinity, selectivity and antiallodynic activity

    European Journal of Medicinal Chemistry, Vol. 177, pp. 47-62

2017

  1. (+)-and (−)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ1antagonist properties and antinociceptive effects

    European Journal of Medicinal Chemistry, Vol. 125, pp. 603-610

2014

  1. Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block

    British Journal of Pharmacology, Vol. 171, Núm. 2, pp. 438-451

  2. Withania coagulans fruit extract reduces oxidative stress and inflammation in kidneys of streptozotocin-induced diabetic rats

    Oxidative Medicine and Cellular Longevity, Vol. 2014

2013

  1. Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea

    Journal of Natural Products, Vol. 76, Núm. 4, pp. 737-740

2012

  1. Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization

    British Journal of Pharmacology, Vol. 166, Núm. 8, pp. 2289-2306

2009

  1. 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice

    Pain, Vol. 141, Núm. 3, pp. 239-247

  2. Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: Studies with selective sigma-1 ligands and sigma-1 knockout mice

    Pain, Vol. 143, Núm. 3, pp. 252-261