Publications (43) VALERIA ALEJANDRA RISSO DIRAZAR publications

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2025

  1. Enzyme Enhancement Through Computational Stability Design Targeting NMR-Determined Catalytic Hotspots

    Journal of the American Chemical Society

  2. Stable and Promiscuous Galactose Oxidases Engineered by Directed Evolution, Atomistic Design, and Ancestral Sequence Reconstruction

    ACS Synthetic Biology, Vol. 14, Núm. 1, pp. 239-246

2023

  1. Immunoanalytical Approach for Detecting and Identifying Ancestral Peptide Biomarkers in Early Earth Analogue Environments

    Analytical Chemistry, Vol. 95, Núm. 12, pp. 5323-5330

  2. Protection of Catalytic Cofactors by Polypeptides as a Driver for the Emergence of Primordial Enzymes

    Molecular Biology and Evolution, Vol. 40, Núm. 6

2022

  1. Efficient Base-Catalyzed Kemp Elimination in an Engineered Ancestral Enzyme

    International journal of molecular sciences, Vol. 23, Núm. 16

  2. Host diversification is concurrent with linear motif evolution in a Mastadenovirus hub protein

    Journal of Molecular Biology, Vol. 434, Núm. 10

2021

  1. A protocol to study bacteriophage adaptation to new hosts

    STAR Protocols, Vol. 2, Núm. 3

  2. Combining Ancestral Reconstruction with Folding-Landscape Simulations to Engineer Heterologous Protein Expression: Engineering heterologous protein expression

    Journal of Molecular Biology, Vol. 433, Núm. 24

  3. Evidence for a role of phenotypic mutations in virus adaptation

    iScience, Vol. 24, Núm. 4

  4. Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase

    Nature Communications, Vol. 12, Núm. 1

  5. Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity

    Nature Communications, Vol. 12, Núm. 1

2020

  1. Ancestral resurrection and directed evolution of fungal mesozoic laccases

    Applied and Environmental Microbiology, Vol. 86, Núm. 14

  2. Consensus Design of an Evolved High-Redox Potential Laccase

    Frontiers in Bioengineering and Biotechnology, Vol. 8

  3. Correction: "Ancestral resurrection and directed evolution of fungal mesozoic laccases" [American Society for Microbiology, (2020), 86, 14 (e00778)] DOI: 10.1128/AEM.00778-20

    Applied and Environmental Microbiology

  4. Enhancing a: De novo enzyme activity by computationally-focused ultra-low-throughput screening

    Chemical Science, Vol. 11, Núm. 24, pp. 6134-6148

  5. Manipulating Conformational Dynamics to Repurpose Ancient Proteins for Modern Catalytic Functions

    ACS Catalysis, Vol. 10, Núm. 9, pp. 4863-4870

2019

  1. Equilibrium partially folded states of B. licheniformis β-lactamase

    European Biophysics Journal, Vol. 48, Núm. 4, pp. 341-348

  2. Non-conservation of folding rates in the thioredoxin family reveals degradation of ancestral unassisted-folding

    Biochemical Journal, Vol. 476, Núm. 23, pp. 3631-3647

2018

  1. Biotechnological and protein-engineering implications of ancestral protein resurrection

    Current Opinion in Structural Biology, Vol. 51, pp. 106-115

  2. Conformational dynamics and enzyme evolution

    Journal of the Royal Society Interface, Vol. 15, Núm. 144