Periodontal and biochemical bone metabolism assessment on a chronic oral anticoagulation population treated with dicoumarins

  1. Daniel López Lacomba 1
  2. Antonio Roa 2
  3. Maximino González Jaranay 2
  4. Gerardo Gómez Moreno 3
  5. Gerardo Moreu Burgos 2
  1. 1 Department of Haematology, Fuenlabrada Hospital, Madrid, Spain
  2. 2 Department of Periodontology, Faculty of Dentistry, University of Granada, Spain
  3. 3 Department of Special Care in Dentistry, Pharmacological Research in Dentistry Group, Faculty of Dentistry, University of Granada, Granada, Spain
Erakutsi afiliazioak +
Aldizkaria:
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Argitalpen urtea: 2017

Alea: 22

Zenbakia: 2

Orrialdeak: 17

Mota: Artikulua

DOI: 10.4317/MEDORAL.21567 DIALNET GOOGLE SCHOLAR lock_openSarbide irekia editor

Beste argitalpen batzuk: Medicina oral, patología oral y cirugía bucal. Ed. inglesa

Garapen Iraunkorreko Helburuak

Laburpena

The aim is to evaluate periodontal alteration and biochemical markers associated with bone turnover in chronic oral with dicoumarins anticoagulant treatment patients. 80 patients treated with oral anticoagulants were divided into 2 cohort: Group A (n=36) 6 month to 1 year with anticoagulant treatment and Group B (n=44) > 2 years with anticoagulant treatment. Clinical evaluation included: Clinical attachment level (CAL), plaque index (PI) and gingival index (GI). Analytically biochemical parameters of bone remodeling (calcium and phosphorus), formation (total acid phosphatase, alkaline phosphatase and osteocalcin) and resorption (tartrate-resistant acid phosphatase and beta-crosslaps) were evaluated. High values of PI (67-100%) especially in men and in Group B were observed. Men with anticoagulation treatment length showed an increased GI (49.167 vs 78.083) while Group B women showed a decreased GI in comparison with Group A (59.389 vs 42.120). Women presented a greater average CAL than men as well as Group B vs Group A but without statistical significance. All biochemical markers were decreased respect to values of general population. Osteocalcin in GroupB women showed a statistically significant outcome vs GroupA (p=0.004). Acid phosphatase (total and tartrate-resistant) has a slight increase in Group B women versus Group A, and Beta-crosslap showed lower values in Group A men than Group B and slightly lower in Group A women versus Group B, without statistical significance. Patients showed a slight to moderate degree of periodontal affectation, especially gingivitis related to bacterial plaque. Periodontal disorders tended to be more severe in Group B. While bone remodeling showed an overall decrease with greater affectation of bone neoformation phenomena, bone destruction tended to recover and normalize in time.

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