Análisis de la prevalencia de tipos de VPH en muestras de citologías ginecológicas en la población no vacunadaEstudio en la Comunidad de Extremadura

Abstract

With the aim of determining the status of HPV infection among unvaccinated women against the virus in Extremadura, 355.938 smears were studied, under an opportunistic screening plan, between 2002 and 2013. The total analyzed cytology corresponds to 173,841 women, including a sample without cytological lesions and no gynecological history of 593 women. The cytological diagnoses were classified attending the consensus of Bethesda (1), with the following results: negative for intraepithelial lesion or malignancy 93.3%; ASC-US, 1%; ASC-H, 0.1%; L-SIL, 1.6%; H-SIL, 0.3%. The diagnosis of squamous cell carcinoma in 42 cases, ACG was held on 55 and 42 adenocarcinoma . The presence of HPV DNA was analyzed by HPV Direct Flow CHIP (Master Diagnostic, Granada, Spain). HPV DNA was detected in 65% of gynecologic cytology tested, with the prevalence of the top ten genotypes, in descending order, as follows: 16 (35%), 31 (15%), 53 (13%), 66 (11%), 42 (9%), 52 (9%) 6 (9%), 58 (8%), 58 (8%), 18 (8%). A crude prevalence infection of 6% and 5.74% when adjusting for age groups identified as world standard population for the year 2010 (2) was observed. 1. Nayar R, Wilbur DC. The Bethesda System for Reporting Cervical Cytology: Definitions, Criteria, and Explanatory Notes. Springer; 2015. 2. Pace M, Cayotte E, Agafitei L, Zupanic T, Wojtyniak B, Gissler M, et al. Revision of the European Standard Population: Report of Eurostat�s Task Force: 2013 Edition. Publications Office; 2013.