Nuevos péptidos, terpenos y alcaloides antitumorales aislados de organismos marinos

Résumé

This Doctoral Thesis describes the extraction and fractionation of different marine invertebrates to obtain metabolites that show cytotoxic activity. For a structural determination of the effects of metabolites, different forms of use of various spectroscopic techniques and mass spectrometry are applied. In addition, cytotoxic activities of the metabolites were evaluated. Chapter 2: From the study of the sponge Cribrochalina sp. was isolated pembamide (1), a highly N-methylated peptide compound. It showed moderate cytotoxic activity against tumor cells. Chapter 3: A new member of the family of njaoaminas called njaoamine I (2) was isolated from the chemical study of the sponge Reniera sp. It showed moderate cytotoxic activity against tumor cells. Chapter 4: The chemical study of soft coral Protodendron repens was reported for the first time, resulting in the isolation of two xenicals, called protoxenicin A (3) and B (4), and whose structural novelty is the presence of a long chain of fatty acid. Chapter 5: Two new cyclic hexapeptides from the ascidia Lissoclinum bistratum, bistratamides M (5) and N (6). They are characterized by having in theis structures oxazole and thiazole rings. These cyclic peptides show moderate cytotoxic activity against human tumor cell lines. In addition, was performed the study of the interaction of Zn2+ with bistratamide K (7) that gave rise to the formation of a mononuclear Zn2+ complex of 7. Chapter 6: Daedophamida (8), a new cyclodepsipeptide, was isolated from the sponge Daedalopelta sp. Daedophamide showed significant cytotoxic activity against human tumor cell lines.