Mecanismos de potenciación de las defensas antioxidantes endógenas frente al estrés oxidativo

Résumé

The aim of this thesis was to establish different strategies which might enhance the endogenous antioxidant defenses and provide the cell with a higher protection against the apparition of oxidative stress, as well as to gain a better understanding on the mechanisms involved in this cellular adaptation. The activation of the antioxidant defenses and induction of oxidative damage both induced by reactive oxygen species are closely related processes. The lower levels of reactive oxygen species that enhance the activity and expression of the antioxidant defenses also induce the apparition of oxidative damage in the cellular components. The intake of antioxidants in moderate dosages above the recommended dietary allowances is effective in enhancing the endogenous antioxidant defenses and decreasing the oxidative damage markers. Therefore, these nutrients are appropriate to increase the antioxidant protection and prevent the apparition of oxidative damage.