Detección de ADN de papilomavirus humano, en el liquen plano mediante hibridación in situ

  1. González Moles, MA 1
  2. González Moles, S 1
  3. Ruiz Ávila, I 2
  4. Rodríguez Archilla, A 1
  5. Bagán, JV
  6. Ceballos Salobreña, A 1
  1. 1 Universidad de Granada
    info

    Universidad de Granada

    Granada, España

    ROR https://ror.org/04njjy449

  2. 2 Hospital general de Jaén
Journal:
Medicina oral

ISSN: 1137-2834

Year of publication: 1999

Volume: 4

Issue: 2

Pages: 391-397

Type: Article

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More publications in: Medicina oral

Abstract

Objectives: Oral fichen planus (OLP) is an inf/ammatory disease which is considered to be a pre-cancerous condition. The association between human papillomavirus (HPV) and malignan! and potentially malignan! lesions and conditions has recently been established. The ailn of this study is to determine the proportion of patients who test positive far specific HPV DNA types 6111, 16118 and 31133135 by in situ DNA hybridization. Study design: in a series of 47 individuals with OLP. Results: Positivity was established far 31.9% of the OLP cases. HPV DNA 31133135 was present in 19.9% (9 cases), whereas HPV DNA 6111 and 31133135 were respective/y present in 12.8% (6 cases) and 8.5% (4 cases). No relationship was observed between HPV DNA positivity and the location ar clinica/ appearance of OLP. Positive H PV DNA 16118 cases were frequently associated with the presence of epithelial dysplasia (p<0.05), anda significantly higher number of koi/ocytic ce/Is was notec/ among HPV positive individuals with OLP (p<0.01 ). Conclusions: we consider that HPV could be responsible for the development of OLP, possibly by triggering the process. HPV 16 and 18 may induce dysplastic alterations in the oral epithelium vía their genes E6 and E7. Furthermore, HPV 16 and 18 could induce dysp/astic alterations in the oral epithelium through the activity of their genes E6 and E7.

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