Tratamiento de la toxicidad cutánea secundaria al tratamiento radioterápico con una crema basada en sH oligopeptide-1 (epidermal growth factor-egf)un estudio piloto

  1. Seral-Gajón, Antonio Luis
  2. Carreras-Sospedra, Ana
  3. López-Jimeno, Carla
  4. Hijano- Berberia, Vanessa
  5. Viedma-Pastor, Mariano
  6. Russo,Gabriella
  7. Mayayo-Falo, Teo
  8. Martínez-Martínez, Fernando
  9. Fernández-Rodríguez, María
Revista:
Actualidad médica

ISSN: 0365-7965

Año de publicación: 2018

Tomo: 103

Número: 804

Páginas: 76-81

Tipo: Artículo

DOI: 10.15568/AM.2018.804.OR04 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Actualidad médica

Resumen

La dermatitis aguda es muy frecuente en pacientes tratados por neoplasias de mama, cabeza, cuello y tumores cutáneos, debido a las elevadas dosis de radiación administradas, y puede afectar hasta el 95% de los pacientes. Tales efectos pueden disminuir la calidad de vida de los pacientes. El objetivo del presente estudio es valorar como medida profiláctica frente a la radiodermatitis, la eficacia de Radio Cream® de Inves Biofarm. Se reclutaron 20 pacientes que precisaban tratamiento radioterápico, con dosis entre 42,72 Gy y 70 Gy. La crema se aplicó durante todo periodo de tratamiento, 2 veces al día. Se evaluó la toxicidad de la piel mediante los criterios del National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE), que evalúan lesiones agudas por la radiación en una escala de 0 a 4. Al finalizar el tratamiento se aprecia un porcentaje del 5%, 65% y 30% para la toxicidad grado 0, 1, 2 respectivamente, sin observarse grado 3 ni 4. En el momento de finalizar el tratamiento, un 70% no presentaban prurito y el 30% grado 1. La puntuación media de los pacientes fue de 8,38 en escala de 1 a 10. Podemos estimar que la crema Radio Cream® se ha mostrado como una opción válida para la prevención de radiodermatitis. Puede impedir o retrasar la aparición de la toxicidad cutánea, contribuyendo al mantenimiento de la calidad de vida de los pacientes y permitir completar el tratamiento radioterápico a las dosis prescritas.

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Fuente de los datos: Dialnet