Evaluación del efecto de lactobacillus reuteri V3401 en individuos adultos obesos con síndrome metabólico sobre biomarcadores de inflamación, riesgo cardiovascular y composición de la microbiota intestinal

Abstract

The alteration of the gastrointestinal microbiota plays an important role in the development of metabolic syndrome (MS), and its modification through the use of different strains of probiotics could constitute a therapeutic alternative for these patients. In this thesis, the effect of the probiotic strain Lactobacillus reuteri (L. reuteri) V3401 on anthropometric parameters, hepatic steatosis, inflammatory markers and gastrointestinal microbiota in patients with MS was evaluated. For this purpose, a randomized, placebo-controlled, double-blind, two-way cross-over nutritional intervention study has been conducted. In this study, no differences were found between the groups in anthropometric parameters or hepatic steatosis, however, in the subjects who were taking the probiotic strain, a decrease in inflammatory parameters and an increase in Akkermansia muciniphila were found. More well-designed studies in humans are needed to confirm these findings.