Implications of PD-L1 Expression in Oral Squamous Cell Carcinomas

  1. Daniel, Lenouvel
unter der Leitung von:
  1. Miguel Ángel González Moles Doktorvater
  2. Pablo Ramos-García Doktorvater

Universität der Verteidigung: Universidad de Granada

Fecha de defensa: 29 von Januar von 2021

Fachbereiche:
  1. ESTOMATOLOGÍA

Art: Dissertation

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Zusammenfassung

In summary, this thesis adds to the understanding of PD-L1 expression in OSCC. Specifically, that PD-L1 expression is increased in non-smokers, non-drinkers and potentially in women as well. That PD-L1 expression is increased in tumours with an intense inflammatory infiltrate. That PD-L1 expression is increased in the epithelium adjacent to the tumour and this may play a role in oncogenesis. Finally, we have shown evidence that the presence of PD-L1 expression in the tumour cell membrane may predict a worse likelihood of survival.