Diferencias sexuales en el efecto de privación alcohólica en ratas

  1. García Burgos, David
  2. Manrique Zuluaga, Tatiana
  3. Gallo, Milagros
  4. González Reyes, Felisa
Revista:
Psicothema

ISSN: 0214-9915

Año de publicación: 2010

Volumen: 22

Número: 4

Páginas: 887-892

Tipo: Artículo

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Otras publicaciones en: Psicothema

Resumen

Son escasos los estudios que han investigado la relación entre edad de inicio en el consumo de alcohol a edades tempranas y riesgo de recaída en la adultez, que puede además ser mayor en hembras según revelan estudios con ratas. El presente estudio evalúa el efecto de privación alcohólica (ADE en inglés) en ratas adultas de ambos sexos que comenzaron la ingesta alcohólica durante la preadolescencia o adolescencia. Durante las exposiciones recibieron libre acceso a agua y a soluciones de etanol al 5, 10 y 20% (v/v). Los efectos de la edad y sexo sobre el ADE en ratas adultas se evaluaron tras repetidos períodos de abstinencia. Los resultados mostraron que solo las hembras incrementaron el consumo de etanol tras la segunda y tercera privación (mostrando ADE), con independencia de la edad de inicio de consumo.

Referencias bibliográficas

  • Becker, J.B., y Hu, M. (2008). Sex differences in drug abuse. Frontiers in Neuroendocrinology, 29(1), 36-47.
  • Carroll, M.E., Lynch, W.J., Roth, M.E., Morgan, A.D., y Cosgrove, K.P. (2004). Sex and estrogen influence drug abuse. Trends in Pharmacological Sciences, 25(5), 273-279.
  • DeWit, D.J., Adlaf, E.M., Offord, D.R., y Ogborne, A.C. (2000). Age at first alcohol use: A risk factor for the development of alcohol disorders. American Journal of Psychiatry, 157(5), 745-750.
  • Díaz-Granados, J.L., y Graham, D.L. (2007). The effects of continuous and intermittent ethanol exposure in adolesence on the aversive properties of ethanol during adulthood. Alcoholism: Clinical and Experimental Research, 31(12), 2020-2027.
  • Ford, M.M., Eldridge, J.C., y Samson, H.H. (2002). Microanalysis of ethanol self-administration: Estrous cycle phase-related changes in consumption patterns. Alcoholism: Clinical and Experimental Research, 26(5), 635-643.
  • Füllgrabe, M.W., Vengeliene, V., y Spanagel, R. (2007). Influence of age at drinking onset on the alcohol deprivation effect and stress-induced drinking in female rats. Pharmacology Biochemistry and Behavior, 86(2), 320-326.
  • García-Burgos, D., González, F., Manrique, T., y Gallo, M. (2009). Patterns of ethanol intake in preadolescent, adolescent and adult Wistar rats under acquisition, maintenance and relapse-like conditions. Alcoholism: Clinical and Experimental Research, 33(1), 1-7.
  • Grant, B.F., y Dawson, D.A. (1997). Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: Results from the national longitudinal alcohol epidemiologic survey. Journal of Substance Abuse, 9(1), 103-110.
  • Hingson, R.W., Heeren, T., y Winter, M.R. (2006). Age of alcohol-dependence onset: Associations with severity of dependence and seeking treatment. Pediatrics, 118(3), 755-763.
  • Juárez, J., y De Tomasi, E.B. (1999). Sex differences in alcohol drinking patterns during forced and voluntary consumption in rats. Alcohol, 19(1), 15-22.
  • Lancaster, F.E., Brown, T.D., Coker, K.L., Elliott, J.A., y Wren, S.B. (1996). Sex differences in alcohol preference and drinking patterns emerge during the early postpubertal period in Sprague-Dawley rats. Alcoholism: Clinical and Experimental Research, 20(6), 1043-1049.
  • Lynch, W.J., Roth, M.E., y Carroll, M.E. (2002). Biological basis of sex differences in drug abuse: Preclinical and clinical studies. Psychopharmacology, 164(2), 121-137.
  • Manrique, T., Gámiz, F., Morón, I., Ballesteros, M.A., y Gallo, M. (2009). Peculiar modulation of taste aversion learning by the time of day in developing rats. Developmental Psychobiology, 51(2), 147-157.
  • McMillen, B.A. (1997). Toward a definition of a valid model of alcoholism: Multiple animal models for multiple diseases. Alcohol, 14(4), 409-419.
  • Oster, S.M., Toalston, J.E., Kuc, K.A., Pommer, T.J., Murphy, J.M., Lumeng, L., Bell, R.L., McBride, W.J., y Rodd, Z.A. (2006). Effects of multiple alcohol deprivations on operant ethanol self-administration by high-alcohol-drinking replicate rat lines. Alcohol, 38(3), 155-164.
  • Prescott, C.A., y Kendler, K.S. (1999). Age at first drink and risk for alcoholism: A noncausal association. Alcoholism: Clinical and Experimental Research, 23(1), 101-107.
  • Rodd-Henricks, Z.A., McKinzie, D.L., Shaikh, S.R., Murphy, J.M., McBride, W.J., Lumeng, L., y Ting-Kai, L. (2000). Alcohol deprivation effect is prolonged in the alcohol preferring (P) rat after repeated deprivations. Alcoholism: Clinical and Experimental Research, 24(1), 8-16.
  • Roman, E., Ploj, K., y Nylander, I. (2004). Maternal separation has no effect on voluntary ethanol intake in female Wistar rats. Alcohol, 33(1), 31-39.
  • Siegmund, S., Vengeliene, V., Singer, M.V., y Spanagel, R. (2005). Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases. Alcoholism: Clinical and Experimental Research, 29(7), 1139-1145.
  • Sinclair, J.D., y Senter, R.J. (1967). Increased preference for ethanol in rats following deprivation. Psychonomic Science, 8, 11-12.
  • Spear, L.P. (2000). The adolescent brain and age-related behavioral manifestations. Neuroscience and Biobehavioral Reviews, 24(4), 417-463.
  • Tambour, S., Brown, L.L., y Crabbe, J.C. (2008). Gender and age at drinking onset affect voluntary alcohol consumption but neither the alcohol deprivation effect nor the response to stress in mice. Alcoholism: Clinical and Experimental Research, 32(12), 2100-2106.
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