El Metronidazol en los agrandamientos gingivales secundarios a Ciclosporina A
- Mesa, FL.
- Osuna, A.
- Aneiros, J.
- Bravo, J.
- Junco, P.
- Del Moral, RG.
- O´Valle, F.
ISSN: 1699-6585
Year of publication: 2002
Volume: 14
Issue: 2
Pages: 69-74
Type: Article
More publications in: Avances en periodoncia e implantología oral
Abstract
Background: Drug-induced gingival overgrowth (GO) remains a significant problem for the periodontologist. Partial and total regressions of this GO have been reported after a short course of antibiotics. Methods: We conducted a double-blind controlled randomized study in order to determine the effect of 7 days of metronidazole treatment (250 mg /3 times day) on the regression of incipient cyclosporin A- induced GO in adult renal transplanted patients. The quantitation of the GO was performed with Image Digital Analysis. Results: At the end of the study, none of the 26 patients in the trial showed complete remission of the GO. Before treatment, the GO index was 0.90 ± 0.16 in the patients treated with metronidazole (MNZ group =13) and 1.11 ± 0.33 in the controls (placebo group =13). At the end of the study (30 days) the GO index score was lower in 54.4% of the MNZ and the difference between groups was statistically significant (MNZ 0.92 ± 0.28 vs. placebo 1.18 ± 0.3, p < 0.05 Student's t test. Conclusions: The results of our present study indicate that a 7-day course of metronidazole does not induce the complete remission of CSA-induced gingival overgrowth but can partially abate the progression of the GO, probably through a decrease in the bacterial overinfection and gingival inflammation.