Estudio de eficacia del producto factor de crecimiento epidérmico + ácido hialurónico fórmula

  1. Vivó Sesé, Inmaculada 1
  2. Plá Miralles, Mª Dolores 1
  3. Carbonell Ripoll, Carolina 1
  4. Ricarte Amorós, Patricia 1
  5. López Cacho, José Manuel 2
  6. Russo, Gabriella 2
  7. Ramírez, Paloma 3
  8. Ruiz Martínez, Adolfina 3
  9. Martínez-Martínez, Fernando 3
  1. 1 Germaine de Capuccini
  2. 2 Inves Biofarm S. L
  3. 3 Universidad de Granada
    info

    Universidad de Granada

    Granada, España

    ROR https://ror.org/04njjy449

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Revista:
Actualidad médica

ISSN: 0365-7965

Any de publicació: 2015

Tom: 100

Número: 795

Pàgines: 76-80

Tipus: Article

DOI: 10.15568/AM.2015.795.OR03 DIALNET GOOGLE SCHOLAR lock_openDIGIBUG editor

Altres publicacions en: Actualidad médica

Objetivos de desarrollo sostenible

Resum

Over time people have cellular aging by decreasing the synthesis of molecules such as hyaluronic acid, important for the maintenance of the skin, and the epidermal growth factor, important in the epidermal regeneration as it has mitogenic capacity on various epithelial cells and fibroblasts. This aging causes loss of elasticity and firmness in the skin and wrinkles. This is why a complex of ultra-facial regeneration composed by hyaluronic acid and epidermal growth factor as active ingredients was developed. This study aims to demonstrate the efficacy of this product in women with facial aging. A random sample of 19 volunteers was formed and it was divided into two groups (A and B). The product was applied with a device to group A and manually to group B. Initially the volunteers were pooled to give them the product with some indications and to take baseline data. The product was applied at 7 (first session) and 21 days (second session) after they first met. In the second session and 15 days after the second session (35 days) data from the skin of volunteers was taken to see the effects over time. The study proved that the product reduces wrinkles by reducing their volume, length, area and depth. It was also found that the benefits are maintained after two sessions of treatment. The device method obtained effects more quickly and was the only one that reduced the depth of the wrinkles. Satisfaction of the volunteers was acceptable too. Therefore, it can be concluded that the product is effective for removing wrinkles, restore elasticity and firmness of the skin and its effects are safe and maintained and even improved over time.

Referències bibliogràfiques

  • An J.J., Eum W.S., Kwon H.S., Koh J.S., Lee S. Y., Baek J. H., Cho Y. J., Kim D. W., Han K. H., Park J., Jang S. H., Choi S. Y., (2013). Protective effects of skin permeable epidermal and fibroblast growth factor against ultraviolet-induced skin damage and human skin wrinkles. Cosmet Dermatol.; 12(4):287-95.
  • Arpicco S., Milla P., Stella B., Dosio F., (2014). Hyaluronic acid conjugates as vectors for the active targeting of drugs, genes and nanocomposites in cancer treatment. Molecules, 17; 19(3):3193-230.
  • Cowman M.K., Matsuoka S., (2005). Experimental approaches to hyaluronan structure. Carbohydrate Research, 340, 791– 809.
  • Ghersetich, I., Lotti, T., Campanile, G., Grappone, C. And Dini, G. (1994). Hyaluronic acid in cutaneous intrinsic aging. Int J Dermatol. 1994 Feb; 33(2):119-22.
  • James G., Rheinward & Howard Green (1977). Epidermal growth factor and the multiplication of cultured human epidermal keratinocites. Nature, 265; (5593): 421-424.
  • Kim D., Kim S. Y., Mun S. K., Rhee S., Kim B. J., (2015). Epidermal growth factor improves the migration and contractility of aged fibroblasts cultured on 3D collagen matrices. Int J Mol Med., 2015.
  • Matsumoto Y., Kuroyanagi Y., (2010). Development of a wound dressing composed of hyaluronic acid sponge containing arginine and epidermal growth factor; J Biomater Sci Polym Ed; 2010.
  • Olczyk P., Mencner Ł., Komosinska-Vassev K., (2014). The role of the extracellular matrix components in cutaneous wound healing. Biomed Res Int.; 2014:747584.
  • Quan T., Fisher G. J., (2015). Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review. Gerontology, 2015.
  • Reenstra, W. R., Yaar, M., and Gilchrest, B. A. (1996). Aging affects epidermal growth factor receptor phosphorylation and traffic kinetics. Exp. Cell Res. 227,252–255.
Fuente de los datos: Dialnet