Presencia de secuencias de papilomavirus humano 16 en los carcinomas orales de células escamosos

  1. GONZALEZ MOLES, M A 1
  2. RUIZ AVILA, I 2
  3. ESTEBAN, F 3
  4. BRAVO, M 1
  5. FERNANDEZ MARTINEZ, J A 1
  6. GONZALEZ MOLES, S 1
  1. 1 Universidad de Granada. Departamento de Estomatología
  2. 2 Universidad de Granada. Departamento de Anatomía Patológica
  3. 3 Universidad de Sevilla. Departamento de Otorrinolaringología
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Journal:
Medicina oral

ISSN: 1137-2834

Year of publication: 1996

Volume: 1

Issue: 2

Pages: 79-84

Type: Article

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More publications in: Medicina oral

Abstract

Objetive: The purpose of this study was to analyze the association between the presence of human papillomavirus (HPV) type 16 and sorne clinical and pathological parameters in oral SCC. Method: 37 oral biopsies from patients with oral squamous cell carcinoma were studied. Along with clinical and histopathological parameters, HPV 16 DNA was analyzed using the polymerase chain reaction ( PCR) technique. An amplified region of E6 ORF was hybridized with a 3' end-labelled oligonucleotide probe. Results: 11 out of 37 (29. 7%) tumors hybridized with HPV 16 DNA sequences. Conclusions: Our results subgest an aetiological implication of HPV-16 in oral SCC genesis. HVP-16-negative tumors presented statistically most frequently with maximal keratin production, compared to positive tumors.

Data source: Dialnet