Análisis de sistemas bucoadhesivos
- Castán Urbano, Herminia 1
- Morales Hernández, María Encarnación 1
- Clares Naveros, Beatriz 1
- Calpena Campmany, Ana Cristina 2
- Ruíz Martínez, María Adolfina 1
- 1 Universidad de Granada, España
- 2 Universidad de Barcelona, España
ISSN: 2340-9894, 0004-2927
Any de publicació: 2013
Volum: 54
Número: 2
Pàgines: 39-43
Tipus: Article
Altres publicacions en: Ars pharmaceutica
Resum
Aim: The aim of this study is to design a bucoadhesive patch for the transbuccal administration of doxepin hydrochloride using different polymers as well as the characterization of these systems for calorimetric analysis and the swelling capacity. Materials and methods: Doxepin hydrochloride was used as well as various polymers; carboxymethylcellulose sodium, hydroxypropylmethyl cellulose and chitosan. Differential scanning calorimetry (DSC) was carried out using a Mettler FP 80 device equipped with a FP 85 oven and the swelling capacity using agar plates. Results: Thermograms obtained patches and physical mixtures where there are endothermic transitions between 30 and 120º C and the endothermic peak of the active principle in binary physical mixtures. Dehydration enthalpy is similar in polymers of carboxymethylcellulose sodium and chitosan (281 J/g), the film having less hydroxypropylmethylcellulose (251 J/g), the percentage of moisture shows that the patches prepared with hydroxypropylmethylcellulose have less tendency to collect water (55.91 %) compared to 67.04 % and 67.30 % with sodium carboxymethylcellulose and chitosan, respectively. Conclusion: The results show that there is compatibility between the components of the formulation and the enthalpy data correlate with the data obtained in the swelling test.
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