Análisis de sistemas bucoadhesivos

  1. Castán Urbano, Herminia 1
  2. Morales Hernández, María Encarnación 1
  3. Clares Naveros, Beatriz 1
  4. Calpena Campmany, Ana Cristina 2
  5. Ruíz Martínez, María Adolfina 1
  1. 1 Universidad de Granada, España
  2. 2 Universidad de Barcelona, España
Revista:
Ars pharmaceutica

ISSN: 2340-9894,  0004-2927

Any de publicació: 2013

Volum: 54

Número: 2

Pàgines: 39-43

Tipus: Article

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Altres publicacions en: Ars pharmaceutica

Resum

Aim: The aim of this study is to design a bucoadhesive patch for the transbuccal administration of doxepin hydrochloride using different polymers as well as the characterization of these systems for calorimetric analysis and the swelling capacity. Materials and methods: Doxepin hydrochloride was used as well as various polymers; carboxymethylcellulose sodium, hydroxypropylmethyl cellulose and chitosan. Differential scanning calorimetry (DSC) was carried out using a Mettler FP 80 device equipped with a FP 85 oven and the swelling capacity using agar plates. Results: Thermograms obtained patches and physical mixtures where there are endothermic transitions between 30 and 120º C and the endothermic peak of the active principle in binary physical mixtures. Dehydration enthalpy is similar in polymers of carboxymethylcellulose sodium and chitosan (281 J/g), the film having less hydroxypropylmethylcellulose (251 J/g), the percentage of moisture shows that the patches prepared with hydroxypropylmethylcellulose have less tendency to collect water (55.91 %) compared to 67.04 % and 67.30 % with sodium carboxymethylcellulose and chitosan, respectively. Conclusion: The results show that there is compatibility between the components of the formulation and the enthalpy data correlate with the data obtained in the swelling test.

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