Does experienced pain affects local brain volumes? Insights from a clinical acute pain model

  1. Laura Torrecillas-Martínez 1
  2. Andrés Catena 2
  3. Francisco O'Valle 3
  4. Miguel Padial-Molina 4
  5. Pablo Galindo-Moreno 4
  1. 1 University of Pennsylvania
    info

    University of Pennsylvania

    Filadelfia, Estados Unidos

    ROR https://ror.org/00b30xv10

  2. 2 Universidad de Granada, Departamento de Psicología Experimental
  3. 3 Universidad de Granada, Departamento de Patología
  4. 4 Universidad de Granada, Departamento de Estomatología
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Journal:
International journal of clinical and health psychology

ISSN: 1697-2600

Year of publication: 2019

Volume: 19

Issue: 2

Pages: 115-123

Type: Article

DOI: 10.1016/J.IJCHP.2019.01.001 DIALNET GOOGLE SCHOLAR

More publications in: International journal of clinical and health psychology

Abstract

Background/Objective:To study pain-brain morphometry associations as a function of post-surgery stages (anesthesia, pain and analgesia) in an acute pain model. Method:Impacted mandible third molar were extracted. Before surgery, an anatomical T1 scan was obtained. Regional brain volumen and subcortical nuclei shapes were obtained. Statistical analyses were done using multiple regression, being pain scores the predictors and voxel volumes, subcortical nuclei volumes and subcortical nuclei shapes, the outcomes. Results:Pain was significantly larger at pain than at anesthesia and analgesia stages, and was higher during anesthesia than during analgesia. Pain intensity was related to grey matter in several cortical (Insula, Mid Frontal and Temporal Gyruses, Precuneus, Anterior Cingulate), and subcortical nuclei (Hippocampus, Thalamus, Putamen, Amygdala), depending of the post-surgical stage. A larger number of brain areas showed significance at pain that at anesthesia and analgesia stages. Conclusions:The relationships of regional brain volumes and subcortical nuclei shapes with pain scores seemed to be unsteady, as they changed with the patient's actual pain stage.

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Funding information

This investigation was partially supported by Research Groups #CTS-138, #CTS-176 and #CTS-1028. ( Junta de Andalucía, Spain). LTM also was supported by the Talentia Scholarship Program of the Regional Ministry for Innovation, Science and Enterprise (Junta de Andalucía) and this research was conducted as part of her PDh project. The authors would like to thank to Unidad de Excelencia Salud, Comportamiento y Cerebro.

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