Valoración de cuerpos amiláceos en epilepsia refractaria

  1. García-Fernández, J. 1
  2. García-Fernández, M. M. 2
  3. García-Fernández, M. 1
  4. Acal-González, C.J. 1
  5. García-del-Moral R. 3
  6. Ríos-Pelegrina, R.M. 3
  1. 1 Universidad de Granada.
  2. 2 Hospital Universitario Son Espases, Palma, Islas Baleares
  3. 3 Hospital Universitario San Cecilio, Instituto de Investigación Biomédica, Universidad de Granada.
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Revista:
Actualidad médica

ISSN: 0365-7965

Any de publicació: 2020

Tom: 105

Número: 810

Pàgines: 103-107

Tipus: Article

DOI: 10.15568/AM.2020.810.OR04 DIALNET GOOGLE SCHOLAR lock_openAccés obert editor

Altres publicacions en: Actualidad médica

Resum

Objectives: The purpose of this study is to check whether there is or not a relationship between CoA density and different clinical parameters of the disease established. Compare the assessment of CoA with Hematoxylin-Eosin technique against PAS staining. It is also intended to check if it exists a relationship between hippocampal CoA density and Nestine overexpression. Methods: Histological analysis of 14 patients. For the counting of the CoA, raw scores were used interchangeably, as well as discretized values on a semi-quantitative scale according to Cherian et al. criteria. The modified Engel scale was used to measure post-surgical evolution. Results: The proportion of CoA in the hippocampus matches the proportion found in different studies: 64.3%. At α=0.05, there is significant evidence to observe that the counting is different depending on the type of staining used in the slides. The average number of CoA is higher with the PAS. It is seen that the density of CoA in the hippocampus and cortex is directly related to its density in parahypocampal structures. With regard to the relation between CoA density and age of onset, there are signs of significance. As well as in the post-surgical evolution. With regard to the duration of the crisis period, was found that both variables are independent. Finally, it is observed that there is a direct association between Nestine overexpression and hippocampal CoA density. Conclusion: In patients with Refractory Epilepsy (ER), CoA presence is commonly verified, with a better evaluation with PAS staining. Respectfully to the relation between CoA density and age of onset, there are signs of significance, as well as post-surgical evolution with the modified Engel scale. It would be convenient to continue with the investigations in this field to contrast the role of CoA in ER.

Referències bibliogràfiques

  • Serrano-Castro PJ, Mauri-Llerda JA, Hernández-Ramos FJ, et al. Adult Prevalence of Epilepsy in Spain: EPIBERIA, a Population-Based Study. The Scientific World Journal. 2015;2015:602710.
  • Kwan P, Brodie MJ. Early identification of refractory epilepsy. The New England Journal of Medicine. 2000;342(5):314-319.
  • Cherian PJ, Radhakrishnan V, Radhakrishnan K. The significance of corpora amylacea in mesial temporal lobe epilepsy. Neurology India. 2003;51:277-279.
  • Van Paesschen W, Revesz T, Duncan JS. Corpora amylacea in hippocampal sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry. 1997;63:513-515.
  • Erdamar S, Zhu ZQ, Hamilton WJ, et al. Corpora amylacea and heat shock protein 27 in Ammon’s horn sclerosis. Journal of Neuropathology and Experimental Neurology. 2000;59(8):698-706.
  • Das A, Balan S, Mathew A, et al. Corpora amylacea deposition in the hippocampus of patients with mesial temporal lobe epilepsy: A new role for an old gene?. Indian Journal of Human Genetics. 2011;17 Suppl 1(Suppl 1):S41-S47.
  • Ribeiro M de C, Barbosa-Coutinho L, Mugnol F, et al. Corpora amylacea in temporal lobe epilepsy associated with hippocampal sclerosis. Arquivos de Neuro-Psiquiatría. 2003;61:942-945.
  • Nishio S, Morioka T, Kawamura T, et al. Corpora amylacea replace the hippocampal pyramidal cell layer in a patient with temporal lobe epilepsy. Epilepsia. 2001;42:960-962
  • Suzuki A, Yokoo H, Kakita A, et al. Phagocytized corpora amylacea as a histological hallmark of astrocytic injury in neuromyelitis optica. Neuropathology. 2012;32(6):587-594.
  • Thom M. Review: Hippocampal sclerosis in epilepsy: a neuropathology review. Neuropathology and Applied Neurobiology. 2014;40(5):520-543.
  • Radhakrishnan A, Radhakrishnan K, Radhakrishnan VV, et al. Corpora amylacea in mesial temporal lobe epilepsy: Clinicopathological correlations. Epilepsy Research. 2007;74:81-90.
  • Estupiñán-Díaz, BO, Morales-Chacón, LM, García-Maeso I, et al. Cuerpos amiláceos en la neocorteza de pacientes con epilepsia del lóbulo temporal y displasia cortical focal. Neurología. 2015;30(2):90-96.
  • Aberastury M, Comas B, García M, et al. Epilepsy surgery in children and adolescents: Report on 43 cases. Cirugía de la epilepsia en niños y adolescentes: experiencia de 43 casos. Archivos Argentinos de Pediatría. 2016;114(5):458-463.
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