Relación de la litiasis renal cálcica recidivante con riesgo de pérdida de densidad mineral ósea y fracturas. Estudio de los marcadores de remodelado óseo como predictores del riesgo de fractura
- Garrido Gómez, Juan 1
- Arrabal Polo, Miguel Ángel 2
- Arrabal Martín, Miguel 2
- Fernández Rodríguez, Luis 1
- Torres Barroso, Javier 1
- Zuluaga Gómez, Armando 2
- 1 Servicio de Cirugía Ortopédica y Traumatología. Complejo Hospitalario Granada. Granada
- 2 Servicio de Urología. Complejo Hospitalario Granada. Granada
ISSN: 1578-9756
Any de publicació: 2013
Volum: 30
Número: 1
Pàgines: 19-26
Tipus: Article
Altres publicacions en: Revista de la Sociedad Andaluza de Traumatología y Ortopedia
Resum
Objective: Establish the cut-off point for markers of bone remodeling marker using ROC curves that allow us to have a selection of patients with bone mineral density loss and a high risk of osteoporotic fracture. Material and methods: Transversal study with 182 patients from eastern Andalusia (Spain), distributed in groups based on lithogenic activity. In addition to the clinical variables, densitometry studies were carried out (DEXA) and the assessment of biochemical markers for bone remodeling in peripheral blood for all patients: β-crosslaps, osteocalcin, β-crosslaps/osteocalcin, 24-hr calciuria and calcium/creatinine in urine after fasting. Results: Significant differences were seen in serum values for alkaline phosphatase, PTHi, osteocalcin, β-crosslaps y β-crosslaps/osteocalcin were higher in the group of patients with serious lithogenic activity, as well as a greater loss of bone density. Discussion: Based on bone remodeling markers, the risk of a patient having serious lithogenic activity can be estimated with a sensitivity of between 75-85%. Thus, we can perform clinical and analytical controls in patients to detect lithiasis activity and avoid the loss of bone mineral density which is also an added risk of osteoporotic bone fracture.