Enfermedad de Paget óseautilidad de los bifosfonatos como terapia
- Emilio González Jiménez
- María José Aguilar Cordero
- Pedro Antonio García López
- Rafael Guisado Barrilao
- Judith Álvarez Ferre
- C. A. Padilla López
ISSN: 1132-8460
Année de publication: 2009
Volumen: 18
Número: 2
Pages: 34-38
Type: Article
D'autres publications dans: Revista Española de Enfermedades Metabólicas Oseas
Résumé
Paget's disease of bone is characterized by the appearance and development of progressive skeletal deformation due to an accelerated rate of bone resorption coupled with osteoblastic activity of similar or equal intensity. This produces bone formation that is structurally disorganized. The parallel development of excessive bone remodelling requires the clinical use of anti-resorptive drugs, such as bisphosphonates. These drugs are very effective in the treatment of patients with Paget's disease because they are able to inhibit overly intense osteoclastic activity, and thus, decrease and regulate the bone turnover process. Unlike other drugs, bisphosphonates generally produce the total remission of symptoms, which means the normalization of biochemical parameters as well as improved bone histology. This paper reviews and discusses the symptoms of Paget's disease of bone so that it can be more effectively treated at healthcare facilities. We also discuss the latest diagnostic methods used as well as different treatments for this disease with a special focus on bisphosphonates, particularly, their chemical composition, usage, and benefits derived from administration.