Seguridad y tolerancia de la prueba de Provocación Bronquial con Manitol Inhalado en la EPOC leve- moderada
- B. Alcázar-Navarrete 1
- F. Castellano Miñán
- P. Santiago Díaz
- O. Ruiz Rodríguez
- P.J. Romero Palacios 1
- 1 Departamento de Medicina, Universidad de Granada
ISSN: 1889-7347
Any de publicació: 2018
Volum: 30
Número: 2
Pàgines: 123-129
Tipus: Article
Altres publicacions en: Revista española de patología torácica
Resum
Introduction: bronchial provocation test with inhaled mannitol (Osmohale®) is and indirect approach to the measurement of bronchial hyperresponsiveness (BHR). Neither its clinical utility in COPD nor the secutiry profile en mild to moderate COPD patients is well kwon. Material and Methods: this was an observational prospective study enrrolling mild to moderate COPD patients in an outpatient setting during stability period. Data about lung fuction and CAT questionaire were collected from all patients. Aproved bronchial provocation test (Osmohale ®) was performed. Results: 72 mild to moderate COPD patients were included. BHR could be assesed in 26% of the sample. There was no drop out due to adverse events. The test was well tolerated, with cough being the most reported adverse event. The test was safe, with a mean FEV1 drop of 10% and a mean performance time of 27 minutes. Conclusions: bronchial provocation test with inhaled manitol is a safe and well tolerated procedure in mild to moderate COPD patients.