Relación entre el control de la presión arterial y la adherencia al tratamiento medida mediante el sistema de receta XXI en Granada (España)

  1. García Corpas, José P. 1
  2. Pareja-Martínez, Elisa 2
  3. Esquivel-Prados, Elisabeth 3
  4. Martínez-Martínez, Fernando 3
  1. 1 Cátedra MJFD Atención Farmacéutica, Univ. de Granada
  2. 2 Universidad de Granada. Cátedra María José Faus Dáder de Atención Farmacéutica. Granada. España
  3. 3 Universidad de Granada. Cátedra María José Faus Dáder de Atención Farmacéutica. Granada
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Zeitschrift:
Ars pharmaceutica

ISSN: 2340-9894,  0004-2927

Datum der Publikation: 2022

Ausgabe: 63

Nummer: 1

Seiten: 56-71

Art: Artikel

DOI: 10.30827/ARS.V63I1.22325 DIALNET GOOGLE SCHOLAR lock_openOpen Access editor

Andere Publikationen in: Ars pharmaceutica

Objetivos de desarrollo sostenible

Zusammenfassung

Background: Treatment adherence has been identified as one of the most relevant factors in achieving adequate blood pressure values in hypertensive patients. Aims: To describe patient adherence to antihypertensive treatment determined by drug collection records of the electronic prescription system and study the relationship between this adherence and blood pressure control. Methods: Cross-sectional study conducted from May 2017 to May 2019, in 6 community pharmacies in the province of Granada (Spain). Patients over 18 years of age who took at least one antihypertensive medication for at least six months were included. Main outcome measure: Blood pressure control and adherence to antihypertensive treatment using the electronic prescription. Results: A total of 95 patients were included in the study. A total of 49 patients (51.6%) showed no blood pressure control, and 29 patients (30.5%) showed suboptimal adherence. The multivariate analysis showed no association between the degree of adherence and the variables included in the study, and blood pressure control was only related to sex (OR: 0.044; 95%CI: 0.005-0.427), to cardiac arrhythmia (OR: 0.004; 95% CI: 0.000-0.106) and to anxiety (OR: 0.109; 95% CI: 0.013-0.933). Conclusion: The prevalence of uncontrolled blood pressure was very high (51.6%), and no association with common sociodemographic risk factors, such as physical activity, smoking, or body mass index, was found. Non-adherence to treatment also had a very high prevalence (30.5%), but it was not associated with disease control.

Bibliographische Referenzen

  • Mancia G, Rosei EA, Azizi M, Burnier M, Clement DL, Coca A, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;3021–2104. Doi:10.1093/eurheartj/ehy339
  • Timmis A, Townsend N, Gale C, Grobbee R, Maniadakis N, Flather M, et al. European Society of Cardiology: Cardiovascular Disease Statistics 2017. Eur Heart J. 2018;39:508–79. Doi: 10.1093/eurheartj/ehx628
  • Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73:691–705. Doi:10.1111/j.1365-2125.2012.04167.x
  • Herttua K, Tabák AG, Martikainen P, Vahtera J, Kivimäki M. Adherence to antihypertensive therapy prior to the first presentation of stroke in hypertensive adults: population-based study. Eur Heart J. 2013;34:2933–9. Doi: 10.1093/eurheartj/eht219
  • Van der Laan DM, Elders PJM, Boons CCLM, Beckeringh JJ, Nijpels G, Hugtenburg JG. Factors associated with antihypertensive medication non-adherence: a systematic review. J Hum Hypertens. 2017;31:687–94. Doi:10.1038/jhh.2017.48
  • Costa FV. Improving Adherence to Treatment and Reducing Economic Costs of Hypertension: The Role of Olmesartan-Based Treatment. High Blood Press Cardiovasc Prev. 2017;24:265–74. doi: 10.1007/s40292-017-0221-4
  • Poulter NR, Borghi C, Parati G, Pathak A, Toli D, Williams B, et al. Medication adherence in hypertension. J Hypertens. 2020;38:579–87. Doi: 10.1093/eurheartj/ehy339
  • Vrijens B, Antoniou S, Burnier M, de la Sierra A, Volpe M. Current Situation of Medication Adherence in Hypertension. Front Pharmacol. 2017;8:100. Doi:10.3389/fphar.2017.00100
  • Hargrove JL, Pate V, Casteel CH, Golightly YM, Loehr LR, Marshall SW, et al. Antihypertensive Adherence Trajectories Among Older Adults in the First Year After Initiation of Therapy. Am J Hypertens. 2017;30:1015–23. Doi: 10.1093/ajh/hpx086
  • Lam WY, Fresco P. Medication Adherence Measures: An Overview. Biomed Res Int. 2015;2015:217047. Doi: 10.1155/2015/217047
  • Osterberg L, Blaschke T. Adherence to medication. N Engl J Med.2005;353:487–97. Doi:10.1056/NEJMra050100
  • Pareja-Martínez E, Esquivel-Prados E, Martínez-Martínez F, García-Corpas JP. Questionnaires on adherence to antihypertensive treatment: a systematic review of published questionnaires and their psychometric properties. Int J Clin Pharm 2020;42:355-365. Doi:10.1007/s11096-020-00981-x
  • Sendra-Lillo J, Martínez-Martínez F, García-Corpas JP, Marín Rivas F, Sabater-Hernández D. Validity of home blood pressure measurements manually registered by patients after an educational session provided by community pharmacists. Blood Press Monit. 2015;20:232–6. Doi: 10.1097/MBP.0000000000000119
  • Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 Practice Guidelines for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. Blood Press. 2018;27:314–40. Doi: 10.1080/08037051.2018.1527177.
  • Márquez-Contreras E, López García-Ramos L de, Martell-Claros N, Gil-Guillen VF, Márquez-Rivero S, Pérez-López E, et al. Validation of the electronic prescription as a method for measuring treatment adherence in hypertension. Patient Educ Couns. 2018;101:1654–60. Doi:10.1016/j.pec.2018.04.009
  • Rubio Castañeda FJ, Tomás Aznar C, Muro Baquero C. Validity, Reliability and Associated Factors of the International Physical Activity Questionnaire Adapted to Elderly (IPAQ-E). Rev Esp Salud Publica. 18 de enero de 2017;91. Doi: 91:e201701004
  • Reuter H, Jordan J. Status of hypertension in Europe. Curr Opin Cardiol. 2019;34:342–9. Doi: 10.1097/HCO.0000000000000642
  • Beaney T, Schutte AE, Tomaszewski M, Ariti C, Burrell LM, Castillo RR, et al. May Measurement Month 2017: an analysis of blood pressure screening results worldwide. Lancet Glob Health 2018;6:e736–43. Doi: 10.1016/S2214-109X(18)30259-6
  • Borghi C, Tubach F, De Backer G, Dallongeville J, Guallar E, Medina J, et al. Lack of control of hypertension in primary cardiovascular disease prevention in Europe: Results from the EURIKA study. Int J Cardiol. 2016;218:83–8. Doi: 10.1016/j.ijcard.2016.05.044
  • Burnier M. Antihypertensive Combination Treatment: State of the Art. Curr Hypertens . 2015;17:51. Doi:10.1007/s11906-015-0562-0
  • Wang YR, Alexander GC, Stafford RS. Outpatient hypertension treatment, treatment intensification, and control in Western Europe and the United States. Arch Intern Med 2007;167:141–7. Doi: 10.1001/archinte.167.2.141
  • Tarrazo M, Pérez-Ríos M, Santiago-Pérez MI, Malvar A, Suanzes J, Hervada X. Changes in tobacco consumption: boom of roll-your-own cigarettes and emergence of e-cigarettes. Gac Sanit. 2017;31:204–9. Doi: 10.1016/j.gaceta.2016.06.002
  • Márquez Contreras E, Gil Guillén V, Casado Martínez JJ, Martel Claros N, de la Figuera Von Wichmann M, Martín de Pablos JL, et al. Análisis de los estudios publicados sobre el incumplimiento terapéutico en el tratamiento de la hipertensión arterial en España entre los años 1984 y 2005. Aten Primaria. 2006;38:325–32. Doi:10.1157/13093369
  • Perseguer-Torregrosa Z, Orozco-Beltrán D, Gil-Guillen VF, Pita-Fernandez S, Carratalá-Munuera C, Pallares-Carratalá V, et al. Magnitude of pharmacological nonadherence in hypertensive patients taking antihypertensive medication from a community pharmacy in Spain. J Manag Care Spec Pharm. 2014;20:1217–25. Doi:10.18553/jmcp.2014.20.12.1217
  • Abegaz TM, Shehab A, Gebreyohannes EA, Bhagavathula AS, Elnour AA. Nonadherence to antihypertensive drugs. Medicine (Baltimore) 2017;96(4):e5641. Doi: 10.1097/MD.0000000000005641
  • Peacock E, Krousel-Wood M. Adherence to Antihypertensive Therapy. Med Clin North Am. 2017;101:229–45. Doi: 10.1016/j.mcna.2016.08.005
  • Alfaro IG. Electronic prescription: limitations and possible improvements to ensure greater adherence to treatments. Rev Esp Salud Pública. 2019;93:e201909070.
Fuente de los datos: Dialnet