Lesiones cutáneas con exacerbación perimenstrualun reto diagnóstico
- Blasco Morente, Gonzalo
- Morales Larios, Elisa
- Valenzuela Salas, Ignacio
- Martínez García, Eliseo A.
- Garrido Colmenero, Cristina
- Martín Castro, Marcos Aurelio
- Latorre Fuentes, José María
ISSN: 0365-7965
Year of publication: 2013
Tome: 98
Issue: 788
Pages: 50-52
Type: Article
More publications in: Actualidad médica
Abstract
Dermatitis herpetiformis (DH) is an autoinmune subepidermal bullous dermatosis of chronic course, considered the cutaneous expression of gluten intolerance. It ?s part of a range of pathologies that have in common the sensitivity to this component, but only a small percentage of patients develop gluten sensitive enteropathy with clinical malabsorption. The clinic is manifested by a predominantly papulovesicular rash pruritic, in extension surfaces and buttocks. Immuno-pathological study may not be specific in some cases, but it ?s considered pathognomonic the presence of IgA granular deposits in the dermoepidermal junction. Treatment is based on strict gluten free diet (GFD) and the additional use of dapsone for cutaneous manifestations. We present two patients with polymorphous and unspecific dermatitis for years and perimenstrual outbreaks, which required multiple treatments and laboratory tests to confirm the diagnosis of DH.