Estado actual de la resistencia a carbapenemes: epidemiología y aspectos microbiológicos

  1. Beatriz Calvo Bernal 1
  2. Miguel Ángel López Rus 1
  1. 1 Universidad de Granada
    info

    Universidad de Granada

    Granada, España

    ROR https://ror.org/04njjy449

Journal:
Actualidad médica

ISSN: 0365-7965

Year of publication: 2022

Tome: 107

Issue: 816

Pages: 110-117

Type: Article

DOI: 10.15568/AM.2022.816.REV02 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Actualidad médica

Abstract

Nowadays, the infections due to carbapenem-resistant microorganism represent a global public health issue; the microorganisms most frequently involved are the gram-negative bacteria. This infections pose a major threat because of their elevated mortality, the lack of appropiate antibiotics and its rapid spread arround the world. The emergence of carbapenemases, which are a type of enzimes that hydrolize carbapenems, is the resistance mecanism more frequently involved. The aim of this literature review is to analyse the epidemiology arround the world and ,overall, in Europe; as well as the microbiological aspects of the carbapenem restistant bateria: carbapenemases can be classified into different types and are detected by several laboratory methods as well as its detection methods in laboratory. All this are key aspects and have a great impact on the clinical management of these infections.

Bibliographic References

  • Cantón R, Akóva M, Carmeli Y, Giske CG, Glupczynski Y, Gniadkowski M, et al. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clinical Microbiology and Infection. 2012. DOI: https://doi.org/10.1111/j.1469-0691.2012.03821.x
  • Cantón R, Huarte R, Morata L, Trillo-Mata JL, Muñoz R, González J, et al. Determining the burden of infectious diseases caused by carbapenem-resistant gram-negative bacteria in Spain. Enferm Infecc Microbiol Clin. 2021.39(4):179-183. DOI: https://doi.org/10.1016/j.eimc.2020.04.009
  • Cercenado E. Detección de enterobacterias productoras de carbapenemasas en la rutina del laboratorio. Rev Esp Quimioter. 2015.
  • Codjoe F, Donkor E. Carbapenem Resistance: A Review. Med Sci [Internet]. 2017;6(1):1. DOI: https://doi.org/10.3390/medsci6010001
  • European Centre for Disease Prevention and Control (ECDC). Rapid risk assessment: Carbapenem-resistant Enterobacteriaceae-26 September 2019. Stockholm. Ecdc. 2019;
  • Halat DH, Sarkis DK, Moubareck CA. Carbapenem-Resistant, Gram-Negative Bacilli: The State of the Art. The State of the Art. In: Antibiotic Resistance: Mechanisms and New Antimicrobial Approaches. Elsevier Inc.; 2016. 93–119. DOI: https://doi.org/10.1016/B978-0-12-803642-6.00005-8
  • Lutgring JD, Limbago BM. The Problem of Carbapenemase-Producing-Carbapenem-Resistant-Enterobacteriaceae Detection. J Clinical Microbiol. 2016. 54(3):529-534. DOI: https://doi.org/10.1128/JCM.02771-15
  • Navarro F, Calvo J, Cantón R, Fernández-Cuenca F, Mirelis B. Detección fenotípica de mecanismos de resistencia en microorganismos gramnegativos. Enfermedades Infecciosas y Microbiologia Clinica. 2011. 29(7):524-534. DOI: https://doi.org/10.1016/j.eimc.2011.03.011
  • Nordmann P, Dortet L, Poirel L. Carbapenem resistance in Enterobacteriaceae: Here is the storm! Trends in Molecular Medicine. 2012. 18(5):263-272. DOI: https://doi.org/10.1016/j.molmed.2012.03.003
  • Rodríguez-Baño J, Cisneros JM, Cobos-Trigueros N, Fresco G, Navarro-San Francisco C, Gudiol C, et al. Diagnosis and antimicrobial treatment of invasive infections due to multidrug-resistant Enterobacteriaceae. Guidelines of the Spanish society of infectious diseases and clinical microbiology. Enferm Infecc Microbiol Clin. 2015. 33(5):337.e1-337.e21. DOI: https://doi.org/10.1016/j.eimc.2014.11.009
  • Sheu CC, Chang YT, Lin SY, Chen YH, Hsueh PR. Infections caused by carbapenem-resistant Enterobacteriaceae: An update on therapeutic options. Vol. 10, Frontiers in Microbiology. 2019. DOI: https://doi.org/10.3389/fmicb.2019.00080
  • Xu L, Sun X, Ma X. Systematic review and meta-analysis of mortality of patients infected with carbapenem-resistant Klebsiella pneumoniae. Ann Clin Microbiol Antimicrob [Internet]. 2017; 16(1):18. DOI: https://doi.org/10.1186/s12941-017-0191-3