Hypertensive patients show higher heart rate response during incremental exercise and elevated arterial age estimation than normotensive adult peersVASCU-HEALTH PROJECT)

  1. Cristian Alvarez 1
  2. Christian Campos-Jara 1
  3. Emmanuel Gomes Ciolac 2
  4. Guimaraes, Guilherme Vega 2
  5. Omar Andrade-Mayorga 3
  6. Johnattan Cano-Montoya 4
  7. Andrade, David C. 5
  8. Pedro Delgado-Floody 3
  9. Alonso-Martínez, Alicia 6
  10. Mikel Izquierdo 6
  11. Igor Cigarroa 7
  1. 1 Universidad Andrés Bello
    info

    Universidad Andrés Bello

    Santiago de Chile, Chile

    ROR https://ror.org/01qq57711

  2. 2 Universidade Estadual Paulista
    info

    Universidade Estadual Paulista

    São Paulo, Brasil

    ROR https://ror.org/00987cb86

  3. 3 Universidad de La Frontera, Temuco, Chile
  4. 4 Universidad San Sebastián, Valdivia
  5. 5 Universidad de Antofagasta
    info

    Universidad de Antofagasta

    Antofagasta, Chile

    ROR https://ror.org/04eyc6d95

  6. 6 Universidad Pública de Navarra
    info

    Universidad Pública de Navarra

    Pamplona, España

    ROR https://ror.org/02z0cah89

  7. 7 Universidad Santo Tomás, Los Ángeles, Chile
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Journal:
Retos: nuevas tendencias en educación física, deporte y recreación

ISSN: 1579-1726,  1988-2041

Year of publication: 2023

Issue: 50

Pages: 25-32

Type: Article

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More publications in: Retos: nuevas tendencias en educación física, deporte y recreación

Abstract

There is limited information regarding heart rate (HR) response from predictive formulae and actual exercise tests between arterial hypertension (HTN) and normotensive adults, as well as about vascular similarities or differences between samples of different blood pressure control. This study aimed 1) to describe and compare the HR during exercise between HTN and normotensive adults and 2) to describe the endothelial function and related vascular parameters in both groups. A descriptive clinical study was conducted with 64 adults (men and women) who were divided into three groups: arterial hypertension (HTN n=26), elevated blood pressure (Ele n=16), or normotensive control (CG n=22). The participants underwent a incremental cycling exercise test of 5 stages, where HR (primary outcome) was measured, and secondary vascular outcomes (percentile classification of the pulse wave velocity (%ILEPWVba), maximum carotid intima-media thickness (cIMTmax), and arterial age among others were measured. In stage 2 of the test (50-100 watts), the HTN group showed significantly higher HR vs. CG (+14 beats/min; p<0.05) and vs. Ele group (+15 beats/min; p<0.05), and in stage 5 (125-250 watts), HTN group showed vs. CG (+22 beats/min; p<0.05). HTN group showed a higher arterial stiffness by %ILEPWVba classification and arterial age estimation than the CG group. In conclusion, HTN patients reported a higher HR response only in two out of five stages of the Astrand cycling exercise test than normotensive peers. Moreover, all groups showed a higher HRpredicted than real HRpeak obtained from the exercise test. These results are displayed with more altered vascular parameters in the HTN group.

Bibliographic References

  • Álvarez, C., Cadore, E. L., Gaya, A. R., Mello, J. B., Reuter, C. P., Delgado-Floody, P., . . . Burgos, A. V. (2021). A descriptive ranking of blood pressure and physical fitness of Latin–American ethnic schoolchildren. Ethnicity & Health, 1-23.
  • Andrade-Mayorga, O., Mancilla, R., Díaz, E., & Alvarez, C. (2020). Heart rate during an exercise test and acute high-intensity interval training in type 2 diabetes. International Journal of Sports Medicine, 41(06), 365-372.
  • Astrand, P., & Stromme, S. (2003). Textbook of Work physiology, physiological bases of exercise fourth edition. In I. Astrand & R. K. P.O, Dahl H, Stromme S. (eds). (Eds.), Leeds: Human Kinetics (pp. 237-272).
  • Brubaker, P. H., & Kitzman, D. W. (2011). Chronotropic incompetence: causes, consequences, and management. Circulation, 123(9), 1010-1020.
  • Colberg, S. R., Sigal, R. J., Yardley, J. E., Riddell, M. C., Dunstan, D. W., Dempsey, P. C., . . . Tate, D. F. (2016). Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association. Diabetes Care, 39(11), 2065-2079. doi:10.2337/dc16-1728
  • Coll, B., & Feinstein, S. B. (2008). Carotid intima-media thickness measurements: Techniques and clinical relevance. Curr Atheroscler Rep, 10(5), 444-450. doi:10.1007/s11883-008-0068-1
  • Fisher, J. P., Young, C. N., & Fadel, P. J. (2015). Autonomic adjustments to exercise in humans. Compr Physiol, 5(2), 475-512. doi:10.1002/cphy.c140022
  • Garber, C. E., Blissmer, B., Deschenes, M. R., Franklin, B. A., Lamonte, M. J., Lee, I. M., . . . American College of Sports, M. (2011). American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc, 43(7), 1334-1359. Retrieved from ://MEDLINE:21694556
  • García-Flores, I., Hernández-Lepe, M. A., Aburto-Corona, J. A., Ortiz-Ortiz, M., Naranjo-Orellana, J., & Gómez-Miranda, L. M. (2023). Efecto del entrenamiento interválico de alta intensidad sobre el comportamiento del sistema nervioso autóno-mo (Effect of high intensity Interval training on the autonomic nervous system). Retos-Nuevas Tendencias En Educacion Fisica Deporte Y Recreacion, 47, 847-852.
  • Heiss, C., Rodriguez-Mateos, A., Bapir, M., Skene, S. S., Sies, H., & Kelm, M. (2022). Flow-mediated dilation reference values for evaluation of endothelial function and cardiovascular health. Cardiovascular Research. doi:10.1093/cvr/cvac095
  • Itoh, H., Kaneko, H., Kiriyama, H., Yoshida, Y., Nakanishi, K., Mizuno, Y., . . . Komuro, I. (2019). Relation between the updated blood pressure classification according to the American College of Cardiology/American Heart Association Guidelines and carotid intima-media thickness. The American Journal of Cardiology, 124(3), 396-401.
  • Karvonen, J., Vuorimaa, T. (1988). Heart rate and exercise intensity during sports activities. Practical application. Sports Medicine, 5(5), 303-311.
  • Keytsman, C., Dendale, P., & Hansen, D. (2015). Chronotropic incompetence during exercise in type 2 diabetes: aetiology, assessment methodology, prognostic impact and therapy. Sports Medicine, 45(7), 985-995.
  • Kim, H. M., Rhee, T.-M., & Kim, H.-L. (2022). Integrated approach of brachial-ankle pulse wave velocity and cardiovascular risk scores for predicting the risk of cardiovascular events. PloS one, 17(4), e0267614.
  • Little, J. P., Gillen, J. B., Percival, M. E., Safdar, A., Tarnopolsky, M. A., Punthakee, Z., . . . Gibala, M. J. (2011). Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes. J Appl Physiol (1985), 111(6), 1554-1560. doi:10.1152/japplphysiol.00921.2011
  • japplphysiol.00921.2011 [pii]
  • Lobato, N. S., Filgueira, F. P., Akamine, E. H., Tostes, R. C., Carvalho, M. H., & Fortes, Z. B. (2012). Mechanisms of endothelial dysfunction in obesity-associated hypertension. Braz J Med Biol Res, 45(5), 392-400. doi:10.1590/s0100-879x2012007500058
  • Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., . . . Members:, L. o. a. F. (2013). 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Journal of hypertension, 31(7), 1281-1357. doi:10.1097/01.hjh.0000431740.32696.cc
  • Mancilla, R., Torres, P., Álvarez, C., Schifferli, I., Sapunar, J., & Díaz, E. (2014). Ejercicio físico interválico de alta intensidad mejora el control glicémico y la capacidad aeróbica en pacientes con intolerancia a la glucosa. Rev Med Chil, 142(1), 34-39.
  • Miyai, N., Arita, M., Miyashita, K., Morioka, I., Shiraishi, T., & Nishio, I. (2002). Blood pressure response to heart rate during exercise test and risk of future hypertension. Hypertension, 39(3), 761-766.
  • Oviedo, G., Niño, O., Bellomío, C., González, R., & Guerra, M. (2015). Entrenamiento, presión arterial y lípidos en adultos con prehipertensión. Retos: nuevas tendencias en educación física, deporte y recreación(27), 67-72.
  • Pescatello, L. S., Buchner, D. M., Jakicic, J. M., Powell, K. E., Kraus, W. E., Bloodgood, B., . . . Physical Activity Guidelines Advisory Committee*, F. T. P. A. G. A. (2019). Physical Activity to Prevent and Treat Hypertension: A Systematic Review. Medicine & Science in Sports & Exercise, 51(6), 1314-1323. doi:10.1249/mss.0000000000001943
  • Ring, M., Eriksson, M. J., Zierath, J. R., & Caidahl, K. (2014). Arterial stiffness estimation in healthy subjects: a validation of oscillometric (Arteriograph) and tonometric (SphygmoCor) techniques. Hypertension Research, 37(11), 999-1007. doi:10.1038/hr.2014.115
  • Román, C., Fernández, M., Acevedo, M., Alarcón, G., Araya, M. V., Barquín, I., . . . Varleta, P. (2019). Ejercicio: una herramienta clave en la prevención cardiovascular. Consenso de la Sociedad Chilena de Cardiología y Cirugía Cardiovascular y de la Sociedad Chilena de Kinesiología en Cardiología y Cirugía Cardiovascular. Revista chilena de cardiología, 38, 149-157. Retrieved from http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-85602019000200149&nrm=iso
  • Thijssen, D. H., Bruno, R. M., van Mil, A. C., Holder, S. M., Faita, F., Greyling, A., . . . Luscher, T. (2019). Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans. European Heart Journal, 40(30), 2534-2547.
  • Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Himmelfarb, C. D., . . . Wright, J. T. (2018). 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension, 71(6), 1269-1324. doi:doi:10.1161/HYP.0000000000000066
  • Yan, J., Cai, X., Zhu, G., Guo, R., Yan, H., & Wang, Y. (2022). A non-invasive blood pressure prediction method based on pulse wave feature fusion. Biomedical Signal Processing and Control, 74, 103523. doi:https://doi.org/10.1016/j.bspc.2022.103523
Data source: Dialnet