Safety considerations during prescription of non-steroidal anti-inflammatory drugs (NSAIDs), through a review of systematic reviews

  1. Olry de Labry Lima, A.
  2. Salamanca-Fernández, E.
  3. Alegre del Rey, E.J.
  4. Matas Hoces, A.
  5. González Vera, M.Á.
  6. Bermúdez Tamayo, C.
Revista:
Anales del sistema sanitario de Navarra

ISSN: 1137-6627

Año de publicación: 2021

Título del ejemplar: 44 (2); mayo - agosto 2021

Volumen: 44

Número: 2

Páginas: 261-273

Tipo: Artículo

DOI: 10.23938/ASSN.0965 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Anales del sistema sanitario de Navarra

Resumen

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs worldwide. This makes it necessary to carry out a comprehensive synthesis of the available evidence on the safe and adequate prescription of NSAIDs in patients with cardiovascular disease, chronic kidney disease, hypertension, heart failure or liver cirrhosis and in general population. For this, a review of systematic reviews was carried out. Data extraction and analysis were performed independently by two reviewers and a narrative synthesis of the results was carried out. The use of NSAIDs is associated with a significantly higher probability of hepatotoxicity and kidney damage, as well as increased risk of exacerbation of heart failure. Taking into account the increased cardiovascular, liver and kidney risk, the prescription of NSAIDs should be carried out with caution, considering the treatment duration and the patient’s situation. For this reason, patients should be informed about their possible health consequences as well as ensuring adequate monitoring of them.

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Información de financiación

This study was financed by Consejer?a de Salud de la Junta de Andaluc?a (Exp. PIN-0155-2017)To Camila Higueras, librarian EASP.

Financiadores

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Fuente de los datos: Dialnet