Hypoconnectivity networks in schizophrenia patientsa voxel-wise meta-analysis of Rs-fMRI
- Silvia Ruiz-Torras 1
- Esteve Gudayol-Ferré 2
- Oscar Fernández-Vazquez 1
- Cristina Cañete-Massé 1
- Maribel Peró-Cebollero 1
- Joan Guàrdia-Olmos 1
-
1
Universitat de Barcelona
info
- 2 Universidad Michoacana San Nicolás de Hidalgo, Mexico
ISSN: 1697-2600
Any de publicació: 2023
Volum: 23
Número: 4
Pàgines: 201-210
Tipus: Article
Altres publicacions en: International journal of clinical and health psychology
Resum
Background In recent years several meta-analyses regarding resting-state functional connectivity in patients with schizophrenia have been published. The authors have used different data analysis techniques: regional homogeneity, seed-based data analysis, independent component analysis, and amplitude of low frequencies. Hence, we aim to perform a meta-analysis to identify connectivity networks with different activation patterns between people diagnosed with schizophrenia and healthy controls using voxel-wise analysis. Method: We collected primary studies exploring whole brain connectivity by functional magnetic resonance imaging at rest in patients with schizophrenia compared with healthy controls. We identified 25 studies included high-quality studies that included 1285 patients with schizophrenia and 1279 healthy controls. Results: The results indicate hypoactivation in the right precentral gyrus and the left superior temporal gyrus of patients with schizophrenia compared with healthy controls. Conclusions: These regions have been linked with some clinical symptoms usually present in Plea with schizophrenia, such as auditory verbal hallucinations, formal thought disorder, and the comprehension and production of gestures.
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