Neofobia Gustativa, Inhibición Latente de la Aversión Gustativa y Memoria de Reconocimiento de Objetos en Ratas Adolescentes
-
1
Universidad de Granada
info
ISSN: 0214-9915, 1886-144X
Año de publicación: 2023
Volumen: 35
Número: 4
Páginas: 423-431
Tipo: Artículo
Otras publicaciones en: Psicothema
Resumen
La adolescencia está marcada por búsqueda de la novedad y acentuada sensibilidad a las propiedades estresantes de los estímulos novedosos. A pesar de la necesidad de probar nuevos alimentos potencialmente tóxicos durante el periodo de crecimiento adolescente, la neofobia gustativa y su atenuación durante este periodo apenas ha sido estudiada. Método: Se evaluaron la neofobia gustativa y los procesos de memoria relacionados en ratas Wistar macho y hembra adolescentes (PND28) y adultas (PND70). En los Experimentos 1 y 2 Se exploró la atenuación de la neofobia gustativa a soluciones de vinagre de sidra (3%) y sacarina sódica (0,1%), respectivamente. En los experimentos 3 y 4, se evaluó también la inhibición latente de aversiones gustativas y la memoria de reconocimiento de objetos. Resultados: Adolescentes y adultos mostraron neofobia gustativa a la sacarina, pero las ratas adolescentes requirieron más exposiciones a la solución de vinagre para reconocerla como segura. No hubo diferencias entre los grupos en los Experimentos 3 and 4. No se hallaron efectos significativos del sexo. Conclusiones: A pesar de la ampliamente aceptada asociación entre adolescencia y reducida neofobia, las ratas adolescentes muestran neofobia al sabor que resulta incluso incrementada cuando se trata de sabores ácidos.
Referencias bibliográficas
- Arenas, M. C., Aguilar, M. A., Montagud-Romero, S., Mateos-García, A., Navarro-Francés, C. I., Miñarro, J., & Rodríguez-Arias, M. (2016). Influence of the novelty-seeking endophenotype on the rewarding effects of psychostimulant drugs in animal models. Current Neuropharmacology, 14(1), 87-100. https://doi.org/10.2174/1570159x13666150921112841
- Bernheim, A., Halfon, O., & Boutrel, B. (2013). Controversies about the enhanced vulnerability of the adolescent brain to develop addiction. Frontiers in Pharmacology, 4, 118. https://doi.org/10.3389/fphar.2013.00118
- Dannenhoffer, C. A., & Spear, L. P. (2016). Age differences in conditioned place preferences and taste aversions to nicotine. Developmental Psychobiology, 58(5), 660-666. https://doi.org/10.1002/dev.21400
- Doremus-Fitzwater, T. L., Varlinskaya, E. I., & Spear, L. P. (2009). Social and non-social anxiety in adolescent and adult rats after repeated restraint. Physiology & Behavior, 97(3-4), 484-494. https://doi.org/10.1016/j.physbeh.2009.03.025
- Doremus-Fitzwater, T. L., Varlinskaya, E. I., & Spear, L. P. (2010). Motivational systems in adolescence: Possible implications for age differences in substance abuse and other risk-taking behaviors. Brain and Cognition, 72(1), 114-123. https://doi.org/10.1016/j.bandc.2009.08.008
- Douglas, L. A., Varlinskaya, E. I., & Spear, L. P. (2003). Novel-object place conditioning in adolescent and adult male and female rats: Effects of social isolation. Physiology & Behavior, 80(2-3), 317-325. https://doi.org/10.1016/j.physbeh.2003.08.003
- Exposito, A. N., Morillas, E., Gomez-Chacon, B., & Gallo, M. (2020). Prefrontal cortex activity patterns during taste neophobia habituation in adult and aged rats. Behavioural Brain Research, 392, 112717. https://doi.org/10.1016/j.bbr.2020.112717
- Friemel, C. M., Spanagel, R., & Schneider, M. (2010). Reward sensitivity for a palatable food reward peaks during pubertal developmental in rats. Frontiers in Behavioral Neuroscience, 4, Article 39. https://doi.org/10.3389/fnbeh.2010.00039
- Gallo, M. (2018). Taste neophobia over the life span. In S. Reilly (Ed.), Food Neophobia (pp. 25-41). Elsevier. https://doi.org/10.1016/B978-0-08-101931-3.00002-1
- Galvan, A., & McGlennen, K. M. (2013). Enhanced striatal sensitivity to aversive reinforcement in adolescents versus adults. Journal of Cognitive Neuroscience, 25(2), 284-296. https://doi.org/10.1162/jocn_a_00326
- Gómez-Chacón, B., Gamiz, F., Foster, T. C., & Gallo, M. (2016). Increased n-ethylmaleimide-sensitive factor expression in amygdala and perirhinal cortex during habituation of taste neophobia. Neural Plasticity, 2016, 2726745. https://doi.org/10.1155/2016/2726745
- Gómez-Chacón, B., Gamiz, F., & Gallo, M. (2012). Basolateral amygdala lesions attenuate safe taste memory-related c-fos expression in the rat perirhinal cortex. Behavioural Brain Research, 230(2), 418-422. https://doi.org/10.1016/j.bbr.2012.02.038
- Grau-Perales, A. B., & Gallo, M. (2020). The auditory context-dependent attenuation of taste neophobia depends on D1 dopamine receptor activity in mice. Behavioural Brain Research, 391, 112687. https://doi.org/10.1016/j.bbr.2020.112687
- Grau-Perales, A. B., Gámiz, F., & Gallo, M. (2021). Effect of hippocampal 6-OHDA lesions on the contextual modulation of taste recognition memory. Behavioural Brain Research, 409, 113320. https://doi.org/10.1016/j.bbr.2021.113320
- Grau-Perales, A. B., Gómez-Chacón, B., & Gallo, M. (2019a). Differential activity pattern of c-Fos in the nucleus accumbens between adult and aged rats during flavor recognition memory. Behavioural Brain Research, 371, 111935. https://doi.org/10.1016/j.bbr.2019.111935
- Grau-Perales, A. B., Gómez-Chacón, B., Morillas, E., & Gallo, M. (2019b). Flavor recognition memory related activity of the posterior piriform cortex in adult and aged rats. Behavioural Brain Research, 360, 196-201. https://doi.org/10.1016/j.bbr.2018.12.016
- Grau-Perales, A. B, Navarro, A., Gómez-Chacón, B., Morón, I. & Gallo, M. (2020). Accumbens and amygdala in taste recognition memory: The role of d1 dopamine receptors. Neurobiology of Learning and Memory, 174, 107277. https://doi.org/10.1016/j.nlm.2020.107277
- Greenhouse, S. W., & Geisser, S. (1959). On methods in the analysis of profile data. Psychometrika, 24(2), 95–112. https://doi.org/10.1007/bf02289823
- Hammerslag, L. R., & Gulley, J. M. (2014). Age and sex differences in reward behavior in adolescent and adult rats. Developmental Psychobiology, 56(4), 611-621. https://doi.org/10.1002/dev.21127
- Kelley, A. E. (2004). Memory and Addiction: Shared neural circuitry and molecular mechanisms. Neuron, 44(1), 161-179. https://doi.org/10.1016/j.neuron.2004.09.016
- Lundberg, S., Hogman, C., & Roman, E. (2019). Adolescent exploratory strategies and behavioral types in the multivariate concentric square field (TM) test. Frontiers in Behavioral Neuroscience, 13, Article 41. https://doi.org/10.3389/fnbeh.2019.00041
- Lynn, D. A., & Brown, G. R. (2010). The ontogeny of anxiety-like behavior in rats from adolescence to adulthood. Developmental Psychobiology, 52(8), 731-739. https://doi.org/10.1002/dev.20468
- Morillas, E., Gomez-Chacon, B., & Gallo, M. (2017). Flavor and object recognition memory impairment induced by excitotoxic lesions of the perirhinal cortex. Neurobiology of Learning and Memory, 144, 230-234. https://doi.org/10.1016/j.nlm.2017.08.002
- Philpot, R. M., & Wecker, L. (2008). Dependence of adolescent noveltyseeking behavior on response phenotype and effects of apparatus scaling. Behavioral Neuroscience, 122(4), 861-875. https://doi.org/10.1037/0735-7044.122.4.861
- Ramsaran, A. I., Sanders, H. R., & Stanton, M. E. (2016). Determinants of object-in-context and object-place-context recognition in the developing rat. Developmental Psychobiology, 58(7), 883-895. https://doi.org/10.1002/dev.21432
- Reilly, S., & Bornovalova, M. A. (2005). Conditioned taste aversión and amygdala lesions in the rat: A critical review. Neuroscience and Biobehavioral Reviews, 29(7), 1067-1088. https://doi.org/10.1016/j.neubiorev.2005.03.025
- Spear, L. P. (2000). The adolescent brain and age-related behavioral manifestations. Neuroscience and Biobehavioral Reviews, 24(4), 417-463. https://doi.org/10.1016/s0149-7634(00)00014-2
- Stansfield, K. H., & Kirstein, C. L. (2006). Effects of novelty on behavior in the adolescent and adult rat. Developmental Psychobiology, 48(1), 10-15. https://doi.org/10.1002/dev.20127
- Vaidya, J. G., Grippo, A. J., Johnson, A. K., & Watson, D. (2004). A comparative developmental study of impulsivity in rats and humans: The role of reward sensitivity. Annals of the New York Academy of Sciences, 1021, 395-398. https://doi.org/10.1196/annals.1308.051
- Varlinskaya, E. I., & Spear, L. P. (2006). Ontogeny of acute tolerance to ethanol-induced social inhibition in Sprague? Dawley Rats. Alcoholism: Clinical and Experimental Research, 30(11), 1833-1844. https://doi.org/10.1111/j.1530-0277.2006.00220.x
- Vetter-O’Hagen, C., Varlinskaya, E., & Spear, L. P. (2009). Sex differences in ethanol intake and sensitivity to aversive effects during adolescence and adulthood. Alcohol and Alcoholism (Oxford, Oxfordshire), 44(6), 547-554. https://doi.org/10.1093/alcalc/agp048
- Vicente, L., & De la Casa, L. G. (2021). Context properties modulate flavor neophobia habituation. Psicothema, 33(4), 617–622. https://doi.org/10.7334/psicothema2021.164
- Wilmouth, C. E., & Spear, L. P. (2009). Hedonic sensitivity in adolescent and adult rats: Taste reactivity and voluntary sucrose consumption. Pharmacology Biochemistry and Behavior, 92(4), 566-573. https://doi.org/10.1016/j.pbb.2009.02.009