Tramadol effects on physical performance and sustained attention during a 20-min indoor cycling time-trial: A randomised controlled trial

  1. Holgado, Darias 1
  2. Zandonai, Thomas 1
  3. Zabala, Mikel 1
  4. Hopker, James 2
  5. Perakakis, Pandelis 3
  6. Luque-Casado, Antonio 4
  7. Ciria, Luis 1
  8. Guerra-Hernandez, Eduardo 1
  9. Sanabria, Daniel 1
  1. 1 Universidad de Granada
    info

    Universidad de Granada

    Granada, España

    ROR https://ror.org/04njjy449

  2. 2 University of Kent
    info

    University of Kent

    Canterbury, Reino Unido

    ROR https://ror.org/00xkeyj56

  3. 3 Loyola University, Sevilla
  4. 4 Pablo Olavide University, Sevilla
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Editorial: Zenodo

Any de publicació: 2018

Tipus: Dataset

DOI: 10.5281/ZENODO.1308615 GOOGLE SCHOLAR lock_openAccés obert editor

Resum

Objectives: To investigate the effect of tramadol on performance during a 20-min cycling time-trial (Exper- iment 1), and to test whether sustained attention would be impaired during cycling after tramadol intake (Experiment 2). Design: Randomized, double-blind, placebo controlled trial. Methods: In Experiment 1, participants completed a cycling time-trial, 120-min after they ingested either tramadol or placebo. In Experiment 2, participants performed a visual oddball task during the time-trial. Electroencephalography measures (EEG) were recorded throughout the session. Results: In Experiment 1, average time-trial power output was higher in the tramadol vs. placebo condition (tramadol: 220 W vs. placebo: 209 W; p < 0.01). In Experiment 2, no differences between conditions were observed in the average power output (tramadol: 234 W vs. placebo: 230 W; p > 0.05). No behavioural differences were found between conditions in the oddball task. Crucially, the time frequency analysis in Experiment 2 revealed an overall lower target-locked power in the beta-band (p < 0.01), and higher alpha suppression (p < 0.01) in the tramadol vs. placebo condition. At baseline, EEG power spectrum was higher under tramadol than under placebo in Experiment 1 while the reverse was true for Experiment 2. Conclusions: Tramadol improved cycling power output in Experiment 1, but not in Experiment 2, which may be due to the simultaneous performance of a cognitive task. Interestingly enough, the EEG data in Experiment 2 pointed to an impact of tramadol on stimulus processing related to sustained attention. Trial registration: EudraCT number: 2015-005056-96.