Supplementary Information.pdf

Resum

<b>ABSTRACT </b> <b>Context: </b>Bile acids (BA) are known for their role in intestinal lipid absorption, and can also play a role as signaling molecules to control energy metabolism. Prior evidence suggests that alterations in circulating BA levels and in the pool of circulating BA are linked to an increased risk of obesity and a higher incidence of T2D in middle-aged adults.<b></b> <b>Objective: </b>To investigate the association between plasma levels of BA with cardiometabolic risk factors in a cohort of well-phenotyped relatively healthy young adults. <b>Methods:</b> Body composition, brown adipose tissue, serum classical cardiometabolic risk factors, and a set of 8 plasma BA (including glyco-conjugated forms) in 136 young adults (age 22.1±2.2 years, 67% women) were measured. <b></b> <b>Results:</b> Plasma levels of CDCA and GUDCA were higher in men than in women, although these differences disappeared after adjusting for body fat percentage. Furthermore, CA, CDCA, DCA, and GDCA levels were positively, yet weakly associated, with lean body mass levels, while GDCA and GLCA levels were negatively associated with ¹⁸F-fluorodeoxyglucose uptake by brown adipose tissue. Interestingly, GCA, GCDCA, and GUDCA were positively associated with glucose and insulin serum levels, HOMA index, LDL-C, TNFa, IL-2 and IL-8 levels, but negatively associated with HDL-C, ApoA1, and adiponectin levels, yet these significant correlations partially disappeared after the inclusion of lean body mass as a confounder. <b>Conclusion:</b> Our findings indicate that plasma levels of BA might be sex-dependent and that are associated with cardiometabolic and inflammatory risk factors in young and relatively healthy adults.<br>