Publications by the researcher in collaboration with Noel Mesa Torres (18)

2022

  1. A single evolutionarily divergent mutation determines the different FAD-binding affinities of human and rat NQO1 due to site-specific phosphorylation

    FEBS Letters, Vol. 596, Núm. 1, pp. 29-41

  2. Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants

    Molecules (Basel, Switzerland), Vol. 27, Núm. 24

2021

  1. Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue

    Redox Biology, Vol. 46

2019

  1. Insight into the specificity and severity of pathogenic mechanisms associated with missense mutations through experimental and structural perturbation analyses

    Human Molecular Genetics, Vol. 28, Núm. 1, pp. 1-15

  2. NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms

    Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1867, Núm. 7-8, pp. 663-676

  3. Phosphorylation compromises FAD binding and intracellular stability of wild-type and cancer-associated NQO1: Insights into flavo-proteome stability

    International Journal of Biological Macromolecules, Vol. 125, pp. 1275-1288

  4. Structural and functional insights on the roles of molecular chaperones in the mistargeting and aggregation phenotypes associated with primary hyperoxaluria type I

    Advances in Protein Chemistry and Structural Biology (Academic Press Inc.), pp. 119-152

2018

  1. Evolutionary divergent suppressor mutations in conformational diseases

    Genes, Vol. 9, Núm. 7

  2. Improving the Activity and Stability of Human Galactokinase for Therapeutic and Biotechnological Applications

    ChemBioChem, Vol. 19, Núm. 10, pp. 1088-1095

2017

  1. Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

    Human Molecular Genetics, Vol. 26, Núm. 18, pp. 3531-3544

2016

  1. Caenorhabditis elegans AGXT-1 is a mitochondrial and temperature-adapted ortholog of peroxisomal human AGT1: New insights into between-species divergence in glyoxylate metabolism

    Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1864, Núm. 9, pp. 1195-1205

  2. Erratum: Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands (Scientific Reports (2016) 6 (20331) DOI: 10.1038/srep20331)

    Scientific Reports

2015

  1. Molecular recognition of PTS-1 cargo proteins by Pex5P: Implications for protein mistargeting in primary hyperoxaluria

    Biomolecules, Vol. 5, Núm. 1, pp. 121-141

2014

  1. The consensus-Based approach for gene/enzyme replacement therapies and crystallization strategies: The case of human alanine-Glyoxylate aminotransferase

    Biochemical Journal, Vol. 462, Núm. 3, pp. 453-463

  2. The lower limits for protein stability and foldability in primary hyperoxaluria type i

    Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1844, Núm. 12, pp. 2355-2365

  3. The metastability of human UDP-galactose 4′-epimerase (GALE) is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding

    Archives of Biochemistry and Biophysics, Vol. 562, pp. 103-114

2013

  1. Structural and energetic basis of protein kinetic destabilization in human phosphoglycerate kinase 1 deficiency

    Biochemistry, Vol. 52, Núm. 7, pp. 1160-1170

  2. The Role of Protein Denaturation Energetics and Molecular Chaperones in the Aggregation and Mistargeting of Mutants Causing Primary Hyperoxaluria Type I

    PLoS ONE, Vol. 8, Núm. 8