BIOMOLECULAS
BIOMOLECULAS
Universidad de Zaragoza
Zaragoza, EspañaPublicaciones en colaboración con investigadores/as de Universidad de Zaragoza (35)
2024
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Structural dynamics and functional cooperativity of human NQO1 by ambient temperature serial crystallography and simulations
Protein Science, Vol. 33, Núm. 4
2023
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Counterintuitive structural and functional effects due to naturally occurring mutations targeting the active site of the disease-associated NQO1 enzyme*
FEBS Journal, Vol. 290, Núm. 7, pp. 1855-1873
2022
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A single evolutionarily divergent mutation determines the different FAD-binding affinities of human and rat NQO1 due to site-specific phosphorylation
FEBS Letters, Vol. 596, Núm. 1, pp. 29-41
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Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity‐Making Mutations
Antioxidants, Vol. 11, Núm. 6
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Different phenotypic outcome due to site-specific phosphorylation in the cancer-associated NQO1 enzyme studied by phosphomimetic mutations
Archives of Biochemistry and Biophysics, Vol. 729
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Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants
Molecules (Basel, Switzerland), Vol. 27, Núm. 24
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Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1
Journal of Personalized Medicine, Vol. 12, Núm. 5
2021
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Intrinsically disordered protein NUPR1 binds to the armadillo-repeat domain of Plakophilin 1
International Journal of Biological Macromolecules, Vol. 170, pp. 549-560
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Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue
Redox Biology, Vol. 46
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The isolated GTPase-activating-protein-related domain of neurofibromin-1 has a low conformational stability in solution
Archives of Biochemistry and Biophysics, Vol. 700
2020
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The catalytic cycle of the antioxidant and cancer-associated human NQO1 enzyme: Hydride transfer, conformational dynamics and functional cooperativity
Antioxidants, Vol. 9, Núm. 9, pp. 1-22
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The isolated armadillo-repeat domain of Plakophilin 1 is a monomer in solution with a low conformational stability
Journal of Structural Biology, Vol. 211, Núm. 3
2019
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Phosphorylation compromises FAD binding and intracellular stability of wild-type and cancer-associated NQO1: Insights into flavo-proteome stability
International Journal of Biological Macromolecules, Vol. 125, pp. 1275-1288
2017
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Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution
Human Molecular Genetics, Vol. 26, Núm. 18, pp. 3531-3544
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Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of polycomb RING1B
Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Núm. 31, pp. E6332-E6341
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Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism
Scientific Reports, Vol. 7
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Thermodynamics of cooperative binding of FAD to human NQO1: Implications to understanding cofactor-dependent function and stability of the flavoproteome
Archives of Biochemistry and Biophysics, Vol. 636, pp. 17-27
2016
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Human COA3 Is an Oligomeric Highly Flexible Protein in Solution
Biochemistry, Vol. 55, Núm. 45, pp. 6209-6220
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The chondroitin sulfate/dermatan sulfate 4-O-endosulfatase from marine bacterium Vibrio sp FC509 is a dimeric species: Biophysical characterization of an endosulfatase
Biochimie, Vol. 131, pp. 85-95
2014
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Biochemical and mutational studies of allantoinase from Bacillus licheniformis CECT 20T
Biochimie, Vol. 99, Núm. 1, pp. 178-188