BIOMOLECULAS
BIOMOLECULAS
Publications (206) Publications in which a researcher has participated View referenced research data.
2025
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Enzyme Enhancement Through Computational Stability Design Targeting NMR-Determined Catalytic Hotspots
Journal of the American Chemical Society
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Redefining the Limits of Functional Continuity in the Early Evolution of P-Loop NTPases
Molecular Biology and Evolution, Vol. 42, Núm. 4
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Stable and Promiscuous Galactose Oxidases Engineered by Directed Evolution, Atomistic Design, and Ancestral Sequence Reconstruction
ACS Synthetic Biology, Vol. 14, Núm. 1, pp. 239-246
2023
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Cell Survival Enabled by Leakage of a Labile Metabolic Intermediate
Molecular biology and evolution, Vol. 40, Núm. 3
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Immunoanalytical Approach for Detecting and Identifying Ancestral Peptide Biomarkers in Early Earth Analogue Environments
Analytical Chemistry, Vol. 95, Núm. 12, pp. 5323-5330
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Protection of Catalytic Cofactors by Polypeptides as a Driver for the Emergence of Primordial Enzymes
Molecular Biology and Evolution, Vol. 40, Núm. 6
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Structure-based discovery and in vitro validation of inhibitors of chloride intracellular channel 4 protein
Computational and Structural Biotechnology Journal, Vol. 21, pp. 688-701
2022
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Active site center redesign increases protein stability preserving catalysis in thioredoxin
Protein Science, Vol. 31, Núm. 9
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An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment
ACS infectious diseases, Vol. 8, Núm. 6, pp. 1107-1115
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Efficient Base-Catalyzed Kemp Elimination in an Engineered Ancestral Enzyme
International journal of molecular sciences, Vol. 23, Núm. 16
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Folding Free Energy Surfaces from Differential Scanning Calorimetry
Methods in Molecular Biology (Humana Press Inc.), pp. 105-116
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Host diversification is concurrent with linear motif evolution in a Mastadenovirus hub protein
Journal of Molecular Biology, Vol. 434, Núm. 10
2021
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A protocol to study bacteriophage adaptation to new hosts
STAR Protocols, Vol. 2, Núm. 3
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Combining Ancestral Reconstruction with Folding-Landscape Simulations to Engineer Heterologous Protein Expression: Engineering heterologous protein expression
Journal of Molecular Biology, Vol. 433, Núm. 24
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Evidence for a role of phenotypic mutations in virus adaptation
iScience, Vol. 24, Núm. 4
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Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase
Nature Communications, Vol. 12, Núm. 1
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Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity
Nature Communications, Vol. 12, Núm. 1
2020
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A quantitative assay to study the lipid selectivity of membrane-associated systems using solution NMR
Chemical Communications, Vol. 56, Núm. 78, pp. 11665-11668
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Ancestral resurrection and directed evolution of fungal mesozoic laccases
Applied and Environmental Microbiology, Vol. 86, Núm. 14
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BANK1 interacts with TRAF6 and MyD88 in innate immune signaling in B cells
Cellular and Molecular Immunology, Vol. 17, Núm. 9, pp. 954-965