BIOMOLECULAS
BIOMOLECULAS
Publicaciones (132) Publicaciones en las que ha participado algún/a investigador/a
2023
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Cell Survival Enabled by Leakage of a Labile Metabolic Intermediate
Molecular biology and evolution, Vol. 40, Núm. 3
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Immunoanalytical Approach for Detecting and Identifying Ancestral Peptide Biomarkers in Early Earth Analogue Environments
Analytical Chemistry, Vol. 95, Núm. 12, pp. 5323-5330
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Protection of Catalytic Cofactors by Polypeptides as a Driver for the Emergence of Primordial Enzymes
Molecular Biology and Evolution, Vol. 40, Núm. 6
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Structure-based discovery and in vitro validation of inhibitors of chloride intracellular channel 4 protein
Computational and Structural Biotechnology Journal, Vol. 21, pp. 688-701
2022
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Active site center redesign increases protein stability preserving catalysis in thioredoxin
Protein Science, Vol. 31, Núm. 9
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An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment
ACS infectious diseases, Vol. 8, Núm. 6, pp. 1107-1115
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Efficient Base-Catalyzed Kemp Elimination in an Engineered Ancestral Enzyme
International journal of molecular sciences, Vol. 23, Núm. 16
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Folding Free Energy Surfaces from Differential Scanning Calorimetry
Methods in Molecular Biology (Humana Press Inc.), pp. 105-116
2021
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A protocol to study bacteriophage adaptation to new hosts
STAR Protocols, Vol. 2, Núm. 3
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Combining Ancestral Reconstruction with Folding-Landscape Simulations to Engineer Heterologous Protein Expression: Engineering heterologous protein expression
Journal of Molecular Biology, Vol. 433, Núm. 24
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Evidence for a role of phenotypic mutations in virus adaptation
iScience, Vol. 24, Núm. 4
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Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase
Nature Communications, Vol. 12, Núm. 1
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Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity
Nature Communications, Vol. 12, Núm. 1
2020
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Ancestral resurrection and directed evolution of fungal mesozoic laccases
Applied and Environmental Microbiology, Vol. 86, Núm. 14
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BANK1 interacts with TRAF6 and MyD88 in innate immune signaling in B cells
Cellular and Molecular Immunology, Vol. 17, Núm. 9, pp. 954-965
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Consensus Design of an Evolved High-Redox Potential Laccase
Frontiers in Bioengineering and Biotechnology, Vol. 8
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Correction: "Ancestral resurrection and directed evolution of fungal mesozoic laccases" [American Society for Microbiology, (2020), 86, 14 (e00778)] DOI: 10.1128/AEM.00778-20
Applied and Environmental Microbiology
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Enhancing a: De novo enzyme activity by computationally-focused ultra-low-throughput screening
Chemical Science, Vol. 11, Núm. 24, pp. 6134-6148
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Manipulating Conformational Dynamics to Repurpose Ancient Proteins for Modern Catalytic Functions
ACS Catalysis, Vol. 10, Núm. 9, pp. 4863-4870
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Naturally-occurring rare mutations cause mild to catastrophic effects in the multifunctional and cancer-associated NQO1 protein
Journal of Personalized Medicine, Vol. 10, Núm. 4, pp. 1-31