I + D FARMACOS
INVESTIGACION Y DESARROLLO DE FARMACOS
Publications (142) Publications in which a researcher has participated
2024
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Editorial: Investigation of the biological properties of natural products using experimental approaches and in silico methods
Frontiers in Chemistry
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Hydroxytyrosyl punicate: A first overview of a novel phenolipid with antiproliferative and antitrypanosomal activity
Journal of Functional Foods, Vol. 117
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Pharmaceutical chemistry: Drugs and their biological targets
De Gruyter, pp. 1-304
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Synthesis and Anti-Diabetic Activity of an 8-Purine Derivative as a Novel DPP-4 Inhibitor in Obese Diabetic Zücker Rats
Drug Design, Development and Therapy, Vol. 18, pp. 1133-1141
2023
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Galantamine Based Novel Acetylcholinesterase Enzyme Inhibitors: A Molecular Modeling Design Approach
Molecules (Basel, Switzerland), Vol. 28, Núm. 3
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Identification of compounds with activity against Trypanosoma cruzi within a collection of synthetic nucleoside analogs
Frontiers in Cellular and Infection Microbiology, Vol. 12
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N-aryltetrahydroisoquinoline derivatives as HA-CD44 interaction inhibitors: Design, synthesis, computational studies, and antitumor effect
European Journal of Medicinal Chemistry, Vol. 258
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New amidine-benzenesulfonamides as iNOS inhibitors for the therapy of the triple negative breast cancer
European Journal of Medicinal Chemistry, Vol. 248
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New bioisosteric sulphur-containing choline kinase inhibitors with a tracked mode of action
European journal of medicinal chemistry, Vol. 246, pp. 115003
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Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme
Purinergic Signalling
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Symmetric 4,6-dialkyl/arylamino-5-nitropyrimidines: theoretical explanation of why aminolysis of alkoxy groups is favoured over chlorine aminolysis in nitro-activated pyrimidines
New Journal of Chemistry, Vol. 47, Núm. 41, pp. 19138-19145
2022
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Anticancer Activity of the Choline Kinase Inhibitor PL48 Is Due to Selective Disruption of Choline Metabolism and Transport Systems in Cancer Cell Lines
Pharmaceutics, Vol. 14, Núm. 2
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Bioactive imidamide-based compounds targeted against nitric oxide synthase
Bioorganic Chemistry, Vol. 120
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Biological Evaluation of New Thienopyridinium and Thienopyrimidinium Derivatives as Human Choline Kinase Inhibitors
Pharmaceutics, Vol. 14, Núm. 4
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NMR spectroscopy study of new imidamide derivatives as nitric oxide synthase inhibitors
Magnetic Resonance in Chemistry, Vol. 60, Núm. 9, pp. 915-923
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Selective Anticancer Therapy Based on a HA-CD44 Interaction Inhibitor Loaded on Polymeric Nanoparticles
Pharmaceutics, Vol. 14, Núm. 4
2021
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3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
Nature Communications, Vol. 12, Núm. 1
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Anticancer and structure activity relationship of non-symmetrical choline kinase inhibitors
Pharmaceutics, Vol. 13, Núm. 9
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Design and Synthesis of 9-Dialkylamino-6-[(1H-1,2,3-triazol-4-yl)methoxy]-9H-purines
ChemRxiv. Cambridge: Cambridge Open Engage; 2021
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Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 36, Núm. 1, pp. 1553-1563