
ANTONIO
ENTRENA GUADIX
Researcher in the period 2009-2018
Publications (92) ANTONIO ENTRENA GUADIX publications
2018
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Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors
Future Medicinal Chemistry, Vol. 10, Núm. 15, pp. 1769-1786
2017
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Choline kinase inhibition and docking studies of a series of 6-(benzylthio)-9H-purin-9-yl-pyridinium derivatives
Medicinal Chemistry Research, Vol. 26, Núm. 11, pp. 2809-2815
2016
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1H and 13C NMR spectral assignments of 1,1′-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))-bispyridinium and -bisquinolinium bromide derivatives
Magnetic Resonance in Chemistry
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Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)
Scientific Reports, Vol. 6
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Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death
Scientific Reports, Vol. 6
2015
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New more polar symmetrical bipyridinic compounds: New strategy for the inhibition of choline kinase α1
Future Medicinal Chemistry, Vol. 7, Núm. 4, pp. 417-436
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New more polar symmetrical choline kinase inhibitors II: Study of setting up a new scaffold for the cancer therapy
Journal of Biological Research (Italy)
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Pharmacophore-Based Virtual Screening to Discover New Active Compounds for Human Choline Kinase α1
Molecular Informatics, Vol. 34, Núm. 6-7, pp. 458-466
2014
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1H, 13C NMR studies of new 3-aminophenol isomers linked to pyridinium salts
Magnetic Resonance in Chemistry, Vol. 52, Núm. 1-2, pp. 40-46
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Choline kinase active site provides features for designing versatile inhibitors
Current Topics in Medicinal Chemistry, Vol. 14, Núm. 23, pp. 2684-2693
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Discovery of a new binding site on human choline kinase α1: Design, synthesis, crystallographic studies, and biological evaluation of asymmetrical bispyridinium derivatives
Journal of Medicinal Chemistry, Vol. 57, Núm. 2, pp. 507-515
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In vitro antiplasmodial and cytotoxic activities of asymmetrical pyridinium derivatives
European Journal of Medicinal Chemistry, Vol. 85, pp. 289-292
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NMR spectroscopic characterization of new nonsymmetrical bispyridinium choline kinase inhibitors
Magnetic Resonance in Chemistry
2013
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Antiproliferative activity, cell cycle, and apoptosis studies of a series of 6-substituted 9H-purin-9-yl-pyridinium derivatives on a human cervical carcinoma cell line
ChemMedChem, Vol. 8, Núm. 8, pp. 1266-1269
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Determination of potential scaffolds for human choline kinase α1 by chemical deconvolution studies
ChemBioChem, Vol. 14, Núm. 11, pp. 1291-1295
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New non-symmetrical choline kinase inhibitors
Bioorganic and Medicinal Chemistry, Vol. 21, Núm. 22, pp. 7146-7154
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Synthesis and biological evaluation of 4,5-dihydro-1H-pyrazole derivatives as potential nNOS/iNOS selective inhibitors. Part 2: Influence of diverse substituents in both the phenyl moiety and the acyl group
Bioorganic and Medicinal Chemistry, Vol. 21, Núm. 14, pp. 4132-4142
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The mechanism of allosteric coupling in choline kinase α1 revealed by the action of a rationally designed inhibitor
Angewandte Chemie - International Edition, Vol. 52, Núm. 17, pp. 4582-4586
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Unbinding pathways from the glucocorticoid receptor shed light on the reduced sensitivity of glucocorticoid ligands to a naturally occurring, clinically relevant mutant receptor
Journal of Medicinal Chemistry, Vol. 56, Núm. 17, pp. 7003-7014
2012
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1H and 13C NMR spectral assignments of pyridinium salts linked to a N-9 or N-3 adenine moiety
Magnetic Resonance in Chemistry, Vol. 50, Núm. 6, pp. 466-469