ANTONIO
ESPINOSA UBEDA
Investigador en el periodo 2002-2011
ANA
CONEJO GARCÍA
CATEDRÁTICA DE UNIVERSIDAD
Publicaciones en las que colabora con ANA CONEJO GARCÍA (29)
2017
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Choline kinase inhibition and docking studies of a series of 6-(benzylthio)-9H-purin-9-yl-pyridinium derivatives
Medicinal Chemistry Research, Vol. 26, Núm. 11, pp. 2809-2815
2014
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Discovery of a new binding site on human choline kinase α1: Design, synthesis, crystallographic studies, and biological evaluation of asymmetrical bispyridinium derivatives
Journal of Medicinal Chemistry, Vol. 57, Núm. 2, pp. 507-515
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In vitro antiplasmodial and cytotoxic activities of asymmetrical pyridinium derivatives
European Journal of Medicinal Chemistry, Vol. 85, pp. 289-292
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NMR spectroscopic characterization of new nonsymmetrical bispyridinium choline kinase inhibitors
Magnetic Resonance in Chemistry
2013
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Antiproliferative activity, cell cycle, and apoptosis studies of a series of 6-substituted 9H-purin-9-yl-pyridinium derivatives on a human cervical carcinoma cell line
ChemMedChem, Vol. 8, Núm. 8, pp. 1266-1269
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The mechanism of allosteric coupling in choline kinase α1 revealed by the action of a rationally designed inhibitor
Angewandte Chemie - International Edition, Vol. 52, Núm. 17, pp. 4582-4586
2012
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1H and 13C NMR spectral assignments of pyridinium salts linked to a N-9 or N-3 adenine moiety
Magnetic Resonance in Chemistry, Vol. 50, Núm. 6, pp. 466-469
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Design, synthesis, theoretical calculations and biological evaluation of new non-symmetrical choline kinase inhibitors
European Journal of Medicinal Chemistry, Vol. 50, pp. 154-162
2011
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Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: A systematic investigation of the influence of linker and cationic heads over affinity and selectivity
Journal of Medicinal Chemistry, Vol. 54, Núm. 8, pp. 2627-2645
2010
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2D-QSAR: The Mathematics behind the Drug Design Methodology
NEW DEVELOPMENTS IN MEDICINAL CHEMISTRY, VOL 1 (BENTHAM SCIENCE PUBL), pp. 79-94
2009
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Homochiral drugs: A demanding tendency of the pharmaceutical industry
Current Medicinal Chemistry, Vol. 16, Núm. 16, pp. 2064-2074
2008
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Design, synthesis and anticancer activity against the MCF-7 cell line of benzo-fused 1,4-dihetero seven- and six-membered tethered pyrimidines and purines
Current Medicinal Chemistry, Vol. 15, Núm. 25, pp. 2614-2631
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From 5-fluorouracil acyclonucleosides to benzo-fused six- and seven-membered rings linked to pyrimidine and purine bases: The shift from differentiating anticancer agents to apoptotic inducers
Expert Opinion on Drug Discovery, Vol. 3, Núm. 10, pp. 1223-1235
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Latest advances on regiospecif ic microwave-assisted synthesis of novel purine derivatives as antitumor agents
Expert Opinion on Therapeutic Patents, Vol. 18, Núm. 2, pp. 211-222
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Regiospecific microwave-assisted synthesis and cytotoxic activity against human breast cancer cells of (RS)-6-substituted-7- or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or -9H-purines
European Journal of Medicinal Chemistry, Vol. 43, Núm. 8, pp. 1742-1748
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Synthesis and anticancer activity of (R,S)-9-(2,3-dihydro-1,4-benzoxathiin- 3-ylmethyl)-9H-purines
ChemMedChem, Vol. 3, Núm. 1, pp. 127-135
2007
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Cyclophanes and bicyclophanes: Fascinating molecules in organic chemistry
Targets in Heterocyclic Systems, Vol. 11, pp. 431-448
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QSAR as a tool for the development of potent antiproliferative agents by inhibition of choline kinase
Current Computer-Aided Drug Design, Vol. 3, Núm. 4, pp. 297-313
2006
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(Q)SAR studies to design new human choline kinase inhibitors as antiproliferative drugs
Current Medicinal Chemistry, Vol. 13, Núm. 11, pp. 1231-1248
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Characterization of latex-antineoplastic drug complexes by differential scanning calorimetry and microphotography
Pharmazie, Vol. 61, Núm. 12, pp. 1009-1013