Publicacións en colaboración con investigadores/as de Hospital Universitario de Canarias (25)

2024

  1. Insights into the pathogenesis of primary hyperoxaluria type I from the structural dynamics of alanine:glyoxylate aminotransferase variants

    FEBS Letters, Vol. 598, Núm. 4, pp. 485-499

2023

  1. Counterintuitive structural and functional effects due to naturally occurring mutations targeting the active site of the disease-associated NQO1 enzyme*

    FEBS Journal, Vol. 290, Núm. 7, pp. 1855-1873

2022

  1. Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity‐Making Mutations

    Antioxidants, Vol. 11, Núm. 6

  2. Different phenotypic outcome due to site-specific phosphorylation in the cancer-associated NQO1 enzyme studied by phosphomimetic mutations

    Archives of Biochemistry and Biophysics, Vol. 729

  3. Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation

    Frontiers in Molecular Biosciences, Vol. 9

  4. Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants

    Molecules (Basel, Switzerland), Vol. 27, Núm. 24

  5. Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1

    Journal of Personalized Medicine, Vol. 12, Núm. 5

2021

  1. Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue

    Redox Biology, Vol. 46

2020

  1. Naturally-occurring rare mutations cause mild to catastrophic effects in the multifunctional and cancer-associated NQO1 protein

    Journal of Personalized Medicine, Vol. 10, Núm. 4, pp. 1-31

2019

  1. A dynamic core in human NQO1 controls the functional and stability effects of ligand binding and their communication across the enzyme dimer

    Biomolecules, Vol. 9, Núm. 11

  2. Insight into the specificity and severity of pathogenic mechanisms associated with missense mutations through experimental and structural perturbation analyses

    Human Molecular Genetics, Vol. 28, Núm. 1, pp. 1-15

  3. Structural and functional insights on the roles of molecular chaperones in the mistargeting and aggregation phenotypes associated with primary hyperoxaluria type I

    Advances in Protein Chemistry and Structural Biology (Academic Press Inc.), pp. 119-152

  4. Systemic Alanine Glyoxylate Aminotransferase mRNA Improves Glyoxylate Metabolism in a Mouse Model of Primary Hyperoxaluria Type 1

    Nucleic Acid Therapeutics, Vol. 29, Núm. 2, pp. 104-113

2018

  1. Evolutionary divergent suppressor mutations in conformational diseases

    Genes, Vol. 9, Núm. 7

  2. Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer

    Handbook of Experimental Pharmacology (Springer New York LLC), pp. 155-190

2017

  1. Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

    Human Molecular Genetics, Vol. 26, Núm. 18, pp. 3531-3544

  2. Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism

    Scientific Reports, Vol. 7

2016

  1. Caenorhabditis elegans AGXT-1 is a mitochondrial and temperature-adapted ortholog of peroxisomal human AGT1: New insights into between-species divergence in glyoxylate metabolism

    Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1864, Núm. 9, pp. 1195-1205

  2. Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

    Scientific Reports, Vol. 6

2015

  1. Molecular recognition of PTS-1 cargo proteins by Pex5P: Implications for protein mistargeting in primary hyperoxaluria

    Biomolecules, Vol. 5, Núm. 1, pp. 121-141