Publications en collaboration avec des chercheurs de Universidad de Zaragoza (17)

2024

  1. Structural dynamics and functional cooperativity of human NQO1 by ambient temperature serial crystallography and simulations

    Protein Science, Vol. 33, Núm. 4

2023

  1. Counterintuitive structural and functional effects due to naturally occurring mutations targeting the active site of the disease-associated NQO1 enzyme*

    FEBS Journal, Vol. 290, Núm. 7, pp. 1855-1873

2022

  1. A single evolutionarily divergent mutation determines the different FAD-binding affinities of human and rat NQO1 due to site-specific phosphorylation

    FEBS Letters, Vol. 596, Núm. 1, pp. 29-41

  2. Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity‐Making Mutations

    Antioxidants, Vol. 11, Núm. 6

  3. Different phenotypic outcome due to site-specific phosphorylation in the cancer-associated NQO1 enzyme studied by phosphomimetic mutations

    Archives of Biochemistry and Biophysics, Vol. 729

  4. Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants

    Molecules (Basel, Switzerland), Vol. 27, Núm. 24

  5. Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1

    Journal of Personalized Medicine, Vol. 12, Núm. 5

2021

  1. Intrinsically disordered protein NUPR1 binds to the armadillo-repeat domain of Plakophilin 1

    International Journal of Biological Macromolecules, Vol. 170, pp. 549-560

  2. Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue

    Redox Biology, Vol. 46

2020

  1. The catalytic cycle of the antioxidant and cancer-associated human NQO1 enzyme: Hydride transfer, conformational dynamics and functional cooperativity

    Antioxidants, Vol. 9, Núm. 9, pp. 1-22

2019

  1. Phosphorylation compromises FAD binding and intracellular stability of wild-type and cancer-associated NQO1: Insights into flavo-proteome stability

    International Journal of Biological Macromolecules, Vol. 125, pp. 1275-1288

2017

  1. Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

    Human Molecular Genetics, Vol. 26, Núm. 18, pp. 3531-3544

  2. Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of polycomb RING1B

    Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Núm. 31, pp. E6332-E6341

  3. Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism

    Scientific Reports, Vol. 7

  4. Thermodynamics of cooperative binding of FAD to human NQO1: Implications to understanding cofactor-dependent function and stability of the flavoproteome

    Archives of Biochemistry and Biophysics, Vol. 636, pp. 17-27

2016

  1. The chondroitin sulfate/dermatan sulfate 4-O-endosulfatase from marine bacterium Vibrio sp FC509 is a dimeric species: Biophysical characterization of an endosulfatase

    Biochimie, Vol. 131, pp. 85-95

2008

  1. Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria

    Journal of Clinical Investigation, Vol. 118, Núm. 8, pp. 2858-2867