Publicaciones (75) Publicaciones de CARMEN MARCO DE LA CALLE

2023

  1. New bioisosteric sulphur-containing choline kinase inhibitors with a tracked mode of action

    European journal of medicinal chemistry, Vol. 246, pp. 115003

2022

  1. Anticancer Activity of the Choline Kinase Inhibitor PL48 Is Due to Selective Disruption of Choline Metabolism and Transport Systems in Cancer Cell Lines

    Pharmaceutics, Vol. 14, Núm. 2

  2. Biological Evaluation of New Thienopyridinium and Thienopyrimidinium Derivatives as Human Choline Kinase Inhibitors

    Pharmaceutics, Vol. 14, Núm. 4

2021

  1. Anticancer and structure activity relationship of non-symmetrical choline kinase inhibitors

    Pharmaceutics, Vol. 13, Núm. 9

2019

  1. Choline kinase inhibitors EB-3D and EB-3P interferes with lipid homeostasis in HepG2 cells

    Scientific Reports, Vol. 9, Núm. 1

2018

  1. 1,2-Diphenoxiethane salts as potent antiplasmodial agents

    Bioorganic and Medicinal Chemistry Letters, Vol. 28, Núm. 14, pp. 2485-2489

  2. Dynamic micellar oligomers of amyloid beta peptides play a crucial role in their aggregation mechanisms

    Physical Chemistry Chemical Physics, Vol. 20, Núm. 31, pp. 20597-20614

  3. Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors

    Future Medicinal Chemistry, Vol. 10, Núm. 15, pp. 1769-1786

2017

  1. Alkylphospholipids: An update on molecular mechanisms and clinical relevance

    Biochimica et Biophysica Acta - Biomembranes, Vol. 1859, Núm. 9, pp. 1657-1667

  2. Choline kinase inhibition and docking studies of a series of 6-(benzylthio)-9H-purin-9-yl-pyridinium derivatives

    Medicinal Chemistry Research, Vol. 26, Núm. 11, pp. 2809-2815

2016

  1. Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)

    Scientific Reports, Vol. 6

  2. Pleiotropic effects of antitumour alkylphospholipids on cholesterol transport and metabolism

    Experimental Cell Research, Vol. 340, Núm. 1, pp. 81-90

2015

  1. Cholesterol homeostasis and autophagic flux in perifosine-treated human hepatoblastoma HepG2 and glioblastoma U-87 MG cell lines

    Biochemical Pharmacology, Vol. 96, Núm. 1, pp. 10-19

  2. New more polar symmetrical bipyridinic compounds: New strategy for the inhibition of choline kinase α1

    Future Medicinal Chemistry, Vol. 7, Núm. 4, pp. 417-436

2014

  1. Antitumoral alkylphospholipids alter cell lipid metabolism

    Anti-Cancer Agents in Medicinal Chemistry, Vol. 14, Núm. 4, pp. 545-558

  2. Choline kinase active site provides features for designing versatile inhibitors

    Current Topics in Medicinal Chemistry, Vol. 14, Núm. 23, pp. 2684-2693

  3. Discovery of a new binding site on human choline kinase α1: Design, synthesis, crystallographic studies, and biological evaluation of asymmetrical bispyridinium derivatives

    Journal of Medicinal Chemistry, Vol. 57, Núm. 2, pp. 507-515

2013

  1. Alkylphospholipids deregulate cholesterol metabolism and induce cell-cycle arrest and autophagy in U-87 MG glioblastoma cells

    Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Vol. 1831, Núm. 8, pp. 1322-1334

  2. Lipid Efflux Mediated by Alkylphospholipids in HepG2 Cells

    Cell Biochemistry and Biophysics, Vol. 66, Núm. 3, pp. 737-746

  3. New non-symmetrical choline kinase inhibitors

    Bioorganic and Medicinal Chemistry, Vol. 21, Núm. 22, pp. 7146-7154