Publications by the researcher in collaboration with ANA CONEJO GARCÍA (43)

2023

  1. Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme

    Purinergic Signalling

2021

  1. Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines

    Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 36, Núm. 1, pp. 1553-1563

  2. Development of bozepinib-loaded nanocapsules for nose-to-brain delivery: Preclinical evaluation in glioblastoma

    Nanomedicine, Vol. 16, Núm. 23, pp. 2095-2115

  3. New insights into cytotoxic mechanisms of bozepinib against glioblastoma

    European Journal of Pharmaceutical Sciences, Vol. 162

2018

  1. Enhancement of tumor cell death by combining gef gene mediated therapy and new 1,4-benzoxazepin-2,6-dichloropurine derivatives in breast cancer cells

    Frontiers in Pharmacology, Vol. 9, Núm. JUL

2017

  1. 1-(Benzenesulfonyl)-1,5-dihydro-4,1-benzoxazepine as a new scaffold for the design of antitumor compounds

    Future Medicinal Chemistry, Vol. 9, Núm. 11, pp. 1129-1140

  2. Antitumoral activity of 1,2-diaminocyclohexane derivatives in breast, colon and skin human cancer cells

    Future Medicinal Chemistry, Vol. 9, Núm. 3, pp. 293-302

  3. Synthesis of 1,4-benzoxathiin-9H-purine derivatives as antiproliferative agents

    Targets in Heterocyclic Systems, Vol. 21, pp. 372-388

2016

  1. 1H and 13C NMR spectral data of p-nitrobenzenesulfonamides and dansylsulfonamides derived from N-alkylated o-(Purinemethyl)anilines

    Magnetic Resonance in Chemistry

2015

  1. P-Nitrobenzenesulfonamides and their fluorescent dansylsulfonamides derived from N-alkylated o-(purine-methyl)anilines as novel antitumour agents

    RSC Advances, Vol. 5, Núm. 93, pp. 76615-76619

2014

  1. Anti-proliferative activity of 2,6-dichloro-9- or 7-(ethoxycarbonylmethyl)- 9H- or 7H-purines against several human solid tumour cell lines

    European Journal of Medicinal Chemistry, Vol. 76, pp. 118-124

  2. HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound

    Oncotarget, Vol. 5, Núm. 11, pp. 3590-3606

2013

  1. Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence

    Drug Design, Development and Therapy, Vol. 7, pp. 1301-1313

  2. Chromatographic enantioresolution of six purine derivatives endowed with anti-human breast cancer activity

    Chromatographia, Vol. 76, Núm. 9-10, pp. 475-482

  3. Enantiospecific synthesis of heterocycles linked to purines: Different apoptosis modulation of enantiomers in breast cancer cells

    Current Medicinal Chemistry, Vol. 20, Núm. 38, pp. 4924-4934

2012

  1. The selective cytotoxic activity in breast cancer cells by an anthranilic alcohol-derived acyclic 5-fluorouracil O,N-acetal is mediated by endoplasmic reticulum stress-induced apoptosis

    European Journal of Medicinal Chemistry, Vol. 50, pp. 376-382

2011

  1. Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: A systematic investigation of the influence of linker and cationic heads over affinity and selectivity

    Journal of Medicinal Chemistry, Vol. 54, Núm. 8, pp. 2627-2645

  2. New (RS)-benzoxazepin-purines with antitumour activity: The chiral switch from (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1- benzoxazepin-3-yl]-9H-purine

    European Journal of Medicinal Chemistry, Vol. 46, Núm. 1, pp. 249-258

  3. Novel substituted quinazolines for potent EGFR tyrosine kinase inhibitors

    Current Medicinal Chemistry, Vol. 18, Núm. 7, pp. 943-963

  4. Syntheses of 2,3-dihydro-1,4-benzodioxins and bioisosteres as structural motifs for biologically active compounds

    Current Organic Chemistry, Vol. 15, Núm. 6, pp. 869-887