Publications in collaboration with researchers from University of Ferrara (46)

2019

  1. Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

    Journal of Medicinal Chemistry, Vol. 62, Núm. 3, pp. 1274-1290

2018

  1. 2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition

    European Journal of Medicinal Chemistry, Vol. 143, pp. 683-698

  2. Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells

    Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 33, Núm. 1, pp. 727-742

2017

  1. Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents

    European Journal of Medicinal Chemistry, Vol. 134, pp. 258-270

  2. Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents

    Scientific Reports, Vol. 7

2016

  1. Design and synthesis of potent in vitro and in vivo anticancer agents based on 1-(3',4',5'-trimethoxyphenyl)-2-Aryl-1H-imidazole

    Scientific Reports, Vol. 6

  2. Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation

    European Journal of Medicinal Chemistry, Vol. 108, pp. 39-52

2015

  1. Design, Synthesis, in Vitro, and in Vivo Anticancer and Antiangiogenic Activity of Novel 3-Arylaminobenzofuran Derivatives Targeting the Colchicine Site on Tubulin

    Journal of Medicinal Chemistry, Vol. 58, Núm. 7, pp. 3209-3222

  2. Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study

    European Journal of Medicinal Chemistry, Vol. 101, pp. 185-204

2014

  1. Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents

    Bioorganic and Medicinal Chemistry, Vol. 22, Núm. 18, pp. 5097-5109

  2. Synthesis and biological evaluation of novel 2-amino-3-aroyl-4-neopentyl-5- substituted thiophene derivatives as allosteric enhancers of the A1 adenosine receptor

    Bioorganic and Medicinal Chemistry, Vol. 22, Núm. 1, pp. 148-166

  3. Synthesis and biological evaluation of novel allosteric enhancers of the A1adenosine receptor based on 2-amino-3-(4′-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene

    Journal of Medicinal Chemistry, Vol. 57, Núm. 18, pp. 7673-7686

2013

  1. Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[ b ]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents

    Journal of Medicinal Chemistry, Vol. 56, Núm. 22, pp. 9296-9309

  2. Synthesis and biological effects of novel 2-amino-3-(4-chlorobenzoyl)-4- substituted thiophenes as allosteric enhancers of the A1 adenosine receptor

    European Journal of Medicinal Chemistry, Vol. 67, pp. 409-427

2012

  1. Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1- yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A 1 adenosine receptor

    Bioorganic and Medicinal Chemistry, Vol. 20, Núm. 2, pp. 996-1007

  2. Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4- arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. Effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor

    Journal of Medicinal Chemistry, Vol. 55, Núm. 17, pp. 7719-7735

2011

  1. One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5- (3′,4′,5′-trimethoxybenzoyl)thiazole: A unique, highly active antimicrotubule agent

    European Journal of Medicinal Chemistry, Vol. 46, Núm. 12, pp. 6015-6024

  2. Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2-(3',4',5'-Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis

    ChemMedChem, Vol. 6, Núm. 10, pp. 1841-1853

2010

  1. Symmetrical α-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation

    Bioorganic and Medicinal Chemistry Letters, Vol. 20, Núm. 9, pp. 2733-2739

  2. Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues

    Journal of Medicinal Chemistry, Vol. 53, Núm. 10, pp. 4248-4258