Publications en collaboration avec des chercheurs de KU Leuven (20)

2018

  1. 2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition

    European Journal of Medicinal Chemistry, Vol. 143, pp. 683-698

2014

  1. Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents

    Bioorganic and Medicinal Chemistry, Vol. 22, Núm. 18, pp. 5097-5109

2013

  1. Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[ b ]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents

    Journal of Medicinal Chemistry, Vol. 56, Núm. 22, pp. 9296-9309

2011

  1. One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5- (3′,4′,5′-trimethoxybenzoyl)thiazole: A unique, highly active antimicrotubule agent

    European Journal of Medicinal Chemistry, Vol. 46, Núm. 12, pp. 6015-6024

  2. Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2-(3',4',5'-Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis

    ChemMedChem, Vol. 6, Núm. 10, pp. 1841-1853

2010

  1. Symmetrical α-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation

    Bioorganic and Medicinal Chemistry Letters, Vol. 20, Núm. 9, pp. 2733-2739

2009

  1. 2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization

    Journal of Medicinal Chemistry, Vol. 52, Núm. 17, pp. 5551-5555

  2. Design, synthesis and structure-activity relationship of 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization

    Bioorganic and Medicinal Chemistry, Vol. 17, Núm. 19, pp. 6862-6871

  3. Discovery of 8-methoxypyrazino[1,2-a]indole as a new potent antiproliferative agent against human leukemia K562 cells. A structure-activity relationship study

    Letters in Drug Design and Discovery, Vol. 6, Núm. 4, pp. 298-303

  4. Hybrid α-bromoacryloylamido chalcones. Design, synthesis and biological evaluation

    Bioorganic and Medicinal Chemistry Letters, Vol. 19, Núm. 7, pp. 2022-2028

2008

  1. Design, synthesis, and biological evaluation of thiophene analogues of chalcones

    Bioorganic and Medicinal Chemistry, Vol. 16, Núm. 10, pp. 5367-5376

  2. Synthesis and biological evaluation of 1-methyl-2-(3′,4′, 5′-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors

    Journal of Medicinal Chemistry, Vol. 51, Núm. 5, pp. 1464-1468

  3. Synthesis and biological evaluation of 2-(3′,4′,5′-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization

    Bioorganic and Medicinal Chemistry, Vol. 16, Núm. 18, pp. 8419-8426

  4. Synthesis and biological evaluation of 2-amino-3-(3′,4′,5′-trimethoxybenzoyl)-6-substituted-4 ,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization

    Bioorganic and Medicinal Chemistry Letters, Vol. 18, Núm. 18, pp. 5041-5045

  5. Synthesis and biological evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a new class of antitubulin agents

    Medicinal Chemistry, Vol. 4, Núm. 6, pp. 558-564

  6. Synthesis and biological evaluation of a series of 2-(3,4,5- trimethoxybenzoyl)-indol-3-yl acetic acid derivatives as potential agents against human leukemia K562 cells

    Letters in Drug Design and Discovery, Vol. 5, Núm. 3, pp. 214-220

2007

  1. Microwave-assisted synthesis of substituted 2,4-diarylthiazoles and their evaluation as anticancer agents

    Letters in Drug Design and Discovery, Vol. 4, Núm. 7, pp. 464-466

  2. Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization

    Journal of Medicinal Chemistry, Vol. 50, Núm. 9, pp. 2273-2277

  3. Synthesis and biological evaluation of 2-amino-3-(3′, 4′, 5′-trimethoxyphenylsulfonyl)-5-aryl thiophenes as a new class of antitubulin agents

    Medicinal Chemistry, Vol. 3, Núm. 6, pp. 507-512

2006

  1. Synthesis and biological evaluation of 2-(3′,4′,5′- trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors

    Journal of Medicinal Chemistry, Vol. 49, Núm. 21, pp. 6425-6428