LUISA CARLOTA
LÓPEZ CARA
PROFESORA TITULAR DE UNIVERSIDAD
University of Padua
Padua, ItaliaPublicaciones en colaboración con investigadores/as de University of Padua (23)
2023
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New bioisosteric sulphur-containing choline kinase inhibitors with a tracked mode of action
European journal of medicinal chemistry, Vol. 246, pp. 115003
2022
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Biological Evaluation of New Thienopyridinium and Thienopyrimidinium Derivatives as Human Choline Kinase Inhibitors
Pharmaceutics, Vol. 14, Núm. 4
2021
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Anticancer and structure activity relationship of non-symmetrical choline kinase inhibitors
Pharmaceutics, Vol. 13, Núm. 9
2020
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Synthesis, biological evaluation, in silico modeling and crystallization of novel small monocationic molecules with potent antiproliferative activity by dual mechanism
European Journal of Medicinal Chemistry, Vol. 207
2019
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Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors
Journal of Medicinal Chemistry, Vol. 62, Núm. 3, pp. 1274-1290
2018
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2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition
European Journal of Medicinal Chemistry, Vol. 143, pp. 683-698
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Choline kinase alpha inhibition by EB-3D triggers cellular senescence, reduces tumor growth and metastatic dissemination in breast cancer
Cancers, Vol. 10, Núm. 10
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EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells
Biochemical Pharmacology, Vol. 155, pp. 213-223
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Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors
Future Medicinal Chemistry, Vol. 10, Núm. 15, pp. 1769-1786
2017
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Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents
European Journal of Medicinal Chemistry, Vol. 134, pp. 258-270
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Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents
Scientific Reports, Vol. 7
2016
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Design and synthesis of potent in vitro and in vivo anticancer agents based on 1-(3',4',5'-trimethoxyphenyl)-2-Aryl-1H-imidazole
Scientific Reports, Vol. 6
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Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)
Scientific Reports, Vol. 6
2015
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Design, Synthesis, in Vitro, and in Vivo Anticancer and Antiangiogenic Activity of Novel 3-Arylaminobenzofuran Derivatives Targeting the Colchicine Site on Tubulin
Journal of Medicinal Chemistry, Vol. 58, Núm. 7, pp. 3209-3222
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New more polar symmetrical bipyridinic compounds: New strategy for the inhibition of choline kinase α1
Future Medicinal Chemistry, Vol. 7, Núm. 4, pp. 417-436
2014
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Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents
Bioorganic and Medicinal Chemistry, Vol. 22, Núm. 18, pp. 5097-5109
2013
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Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[ b ]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents
Journal of Medicinal Chemistry, Vol. 56, Núm. 22, pp. 9296-9309
2011
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One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5- (3′,4′,5′-trimethoxybenzoyl)thiazole: A unique, highly active antimicrotubule agent
European Journal of Medicinal Chemistry, Vol. 46, Núm. 12, pp. 6015-6024
2010
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Symmetrical α-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation
Bioorganic and Medicinal Chemistry Letters, Vol. 20, Núm. 9, pp. 2733-2739
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Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues
Journal of Medicinal Chemistry, Vol. 53, Núm. 10, pp. 4248-4258