Publicaciones (90) Publicaciones de LUISA CARLOTA LÓPEZ CARA

2024

  1. Directing novel ChoKα1 inhibitors using MamC-mediated biomimetic magnetic nanoparticles: a way to improve specificity and efficiency

    Bioorganic Chemistry, Vol. 151

2023

  1. New bioisosteric sulphur-containing choline kinase inhibitors with a tracked mode of action

    European journal of medicinal chemistry, Vol. 246, pp. 115003

2022

  1. Anticancer Activity of the Choline Kinase Inhibitor PL48 Is Due to Selective Disruption of Choline Metabolism and Transport Systems in Cancer Cell Lines

    Pharmaceutics, Vol. 14, Núm. 2

  2. Biological Evaluation of New Thienopyridinium and Thienopyrimidinium Derivatives as Human Choline Kinase Inhibitors

    Pharmaceutics, Vol. 14, Núm. 4

2021

  1. 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

    Nature Communications, Vol. 12, Núm. 1

  2. Anticancer and structure activity relationship of non-symmetrical choline kinase inhibitors

    Pharmaceutics, Vol. 13, Núm. 9

  3. New compounds with bioisosteric replacement of classic choline kinase inhibitors show potent antiplasmodial activity

    Pharmaceutics, Vol. 13, Núm. 11

2020

  1. Crystal structure of the apo and the adp-bound form of choline kinase from plasmodium falciparum

    Crystals, Vol. 10, Núm. 7, pp. 1-13

  2. Synthesis, biological evaluation, in silico modeling and crystallization of novel small monocationic molecules with potent antiproliferative activity by dual mechanism

    European Journal of Medicinal Chemistry, Vol. 207

  3. Targeting Aryl hydrocarbon receptor for next-generation immunotherapies: Selective modulators (SAhRMs) versus rapidly metabolized ligands (RMAhRLs)

    European Journal of Medicinal Chemistry, Vol. 185

2019

  1. Biomimetic magnetic nanocarriers drive choline kinase alpha inhibitor inside cancer cells for combined chemo-hyperthermia therapy

    Pharmaceutics, Vol. 11, Núm. 8

  2. Choline kinase inhibitors EB-3D and EB-3P interferes with lipid homeostasis in HepG2 cells

    Scientific Reports, Vol. 9, Núm. 1

  3. Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

    Journal of Medicinal Chemistry, Vol. 62, Núm. 3, pp. 1274-1290

2018

  1. 1,2-Diphenoxiethane salts as potent antiplasmodial agents

    Bioorganic and Medicinal Chemistry Letters, Vol. 28, Núm. 14, pp. 2485-2489

  2. 2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition

    European Journal of Medicinal Chemistry, Vol. 143, pp. 683-698

  3. Choline kinase alpha inhibition by EB-3D triggers cellular senescence, reduces tumor growth and metastatic dissemination in breast cancer

    Cancers, Vol. 10, Núm. 10

  4. EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells

    Biochemical Pharmacology, Vol. 155, pp. 213-223

  5. Enhancement of tumor cell death by combining gef gene mediated therapy and new 1,4-benzoxazepin-2,6-dichloropurine derivatives in breast cancer cells

    Frontiers in Pharmacology, Vol. 9, Núm. JUL

  6. Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors

    Future Medicinal Chemistry, Vol. 10, Núm. 15, pp. 1769-1786

  7. Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells

    Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 33, Núm. 1, pp. 727-742