Publications by the researcher in collaboration with JOSÉ ANTONIO GAVIRA GALLARDO (16)

2023

  1. Protection of Catalytic Cofactors by Polypeptides as a Driver for the Emergence of Primordial Enzymes

    Molecular Biology and Evolution, Vol. 40, Núm. 6

2021

  1. Combining Ancestral Reconstruction with Folding-Landscape Simulations to Engineer Heterologous Protein Expression: Engineering heterologous protein expression

    Journal of Molecular Biology, Vol. 433, Núm. 24

  2. Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase

    Nature Communications, Vol. 12, Núm. 1

  3. Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity

    Nature Communications, Vol. 12, Núm. 1

2020

  1. Enhancing a: De novo enzyme activity by computationally-focused ultra-low-throughput screening

    Chemical Science, Vol. 11, Núm. 24, pp. 6134-6148

2019

  1. Non-conservation of folding rates in the thioredoxin family reveals degradation of ancestral unassisted-folding

    Biochemical Journal, Vol. 476, Núm. 23, pp. 3631-3647

2017

  1. De novo active sites for resurrected Precambrian enzymes

    Nature Communications, Vol. 8

2015

  1. Evolution of Conformational Dynamics Determines the Conversion of a Promiscuous Generalist into a Specialist Enzyme

    Molecular Biology and Evolution, Vol. 32, Núm. 1, pp. 132-143

  2. Mutational studies on resurrected ancestral proteins reveal conservation of site-specific amino acid preferences throughout evolutionary history

    Molecular Biology and Evolution, Vol. 32, Núm. 2, pp. 440-455

2014

  1. Phenotypic comparisons of consensus variants versus laboratory resurrections of Precambrian proteins

    Proteins: Structure, Function and Bioinformatics, Vol. 82, Núm. 6, pp. 887-896

  2. Thermostable and promiscuous Precambrian proteins

    Environmental microbiology, Vol. 16, Núm. 6, pp. 1485-1489

2013

  1. Conservation of protein structure over four billion years

    Structure, Vol. 21, Núm. 9, pp. 1690-1697

  2. Erratum: Hyperstability and substrate promiscuity in laboratory resurrections of precambrian β-lactamases (Journal of the American Chemical Society (2013) 135 (2899-2902) DOI:10.1021/ja311630a)

    Journal of the American Chemical Society

  3. Hyperstability and substrate promiscuity in laboratory resurrections of precambrian β-lactamases

    Journal of the American Chemical Society, Vol. 135, Núm. 8, pp. 2899-2902

2010

  1. Modulation of buried ionizable groups in proteins with engineered surface charge

    Journal of the American Chemical Society, Vol. 132, Núm. 4, pp. 1218-1219

2008

  1. Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis

    Journal of Biological Chemistry, Vol. 283, Núm. 40, pp. 27121-27129