Publicaciones (18) Publicaciones de ENCARNACIÓN MEDINA CARMONA

2023

  1. Cell Survival Enabled by Leakage of a Labile Metabolic Intermediate

    Molecular biology and evolution, Vol. 40, Núm. 3

  2. Structure-based discovery and in vitro validation of inhibitors of chloride intracellular channel 4 protein

    Computational and Structural Biotechnology Journal, Vol. 21, pp. 688-701

2022

  1. An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment

    ACS infectious diseases, Vol. 8, Núm. 6, pp. 1107-1115

2020

  1. A quantitative assay to study the lipid selectivity of membrane-associated systems using solution NMR

    Chemical Communications, Vol. 56, Núm. 78, pp. 11665-11668

  2. Chagas Disease: Current View of an Ancient and Global Chemotherapy Challenge

    ACS Infectious Diseases, Vol. 6, Núm. 11, pp. 2830-2843

2019

  1. Insight into the specificity and severity of pathogenic mechanisms associated with missense mutations through experimental and structural perturbation analyses

    Human Molecular Genetics, Vol. 28, Núm. 1, pp. 1-15

  2. New polyamine drugs as more effective antichagas agents than benznidazole in both the acute and chronic phases

    European Journal of Medicinal Chemistry, Vol. 164, pp. 27-46

  3. Phosphorylation compromises FAD binding and intracellular stability of wild-type and cancer-associated NQO1: Insights into flavo-proteome stability

    International Journal of Biological Macromolecules, Vol. 125, pp. 1275-1288

  4. Synthesis and biological evaluation of new long-chain squaramides as anti-chagasic agents in the BALB/c mouse model

    Bioorganic and Medicinal Chemistry, Vol. 27, Núm. 5, pp. 865-879

2018

  1. Second Generation of Mannich Base-Type Derivatives with in Vivo Activity against Trypanosoma cruzi

    Journal of Medicinal Chemistry, Vol. 61, Núm. 13, pp. 5643-5663

  2. Synthesis and Biological in vitro and in vivo Evaluation of 2-(5-Nitroindazol-1-yl)ethylamines and Related Compounds as Potential Therapeutic Alternatives for Chagas Disease

    ChemMedChem, Vol. 13, Núm. 19, pp. 2104-2118

2017

  1. A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R

    FEBS Letters, Vol. 591, Núm. 18, pp. 2826-2835

  2. Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

    Human Molecular Genetics, Vol. 26, Núm. 18, pp. 3531-3544

  3. Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism

    Scientific Reports, Vol. 7

2016

  1. Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

    Scientific Reports, Vol. 6

  2. Erratum: Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands (Scientific Reports (2016) 6 (20331) DOI: 10.1038/srep20331)

    Scientific Reports

  3. Natural small molecules as stabilizers and activators of cancer-associated NQO1 polymorphisms

    Current Drug Targets, Vol. 17, Núm. 13, pp. 1506-1514

  4. The chondroitin sulfate/dermatan sulfate 4-O-endosulfatase from marine bacterium Vibrio sp FC509 is a dimeric species: Biophysical characterization of an endosulfatase

    Biochimie, Vol. 131, pp. 85-95