ANATOMÍA Y EMBRIOLOGÍA HUMANA
Departamento
JOAQUÍN MARÍA
CAMPOS ROSA
Investigador desde null
Publicaciones en las que colabora con JOAQUÍN MARÍA CAMPOS ROSA (37)
2021
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Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 36, Núm. 1, pp. 1553-1563
2018
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Enhancement of tumor cell death by combining gef gene mediated therapy and new 1,4-benzoxazepin-2,6-dichloropurine derivatives in breast cancer cells
Frontiers in Pharmacology, Vol. 9, Núm. JUL
2017
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1-(Benzenesulfonyl)-1,5-dihydro-4,1-benzoxazepine as a new scaffold for the design of antitumor compounds
Future Medicinal Chemistry, Vol. 9, Núm. 11, pp. 1129-1140
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Antitumoral activity of 1,2-diaminocyclohexane derivatives in breast, colon and skin human cancer cells
Future Medicinal Chemistry, Vol. 9, Núm. 3, pp. 293-302
2015
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P-Nitrobenzenesulfonamides and their fluorescent dansylsulfonamides derived from N-alkylated o-(purine-methyl)anilines as novel antitumour agents
RSC Advances, Vol. 5, Núm. 93, pp. 76615-76619
2014
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Anti-proliferative activity of 2,6-dichloro-9- or 7-(ethoxycarbonylmethyl)- 9H- or 7H-purines against several human solid tumour cell lines
European Journal of Medicinal Chemistry, Vol. 76, pp. 118-124
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HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound
Oncotarget, Vol. 5, Núm. 11, pp. 3590-3606
2013
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Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence
Drug Design, Development and Therapy, Vol. 7, pp. 1301-1313
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Enantiospecific synthesis of heterocycles linked to purines: Different apoptosis modulation of enantiomers in breast cancer cells
Current Medicinal Chemistry, Vol. 20, Núm. 38, pp. 4924-4934
2012
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The selective cytotoxic activity in breast cancer cells by an anthranilic alcohol-derived acyclic 5-fluorouracil O,N-acetal is mediated by endoplasmic reticulum stress-induced apoptosis
European Journal of Medicinal Chemistry, Vol. 50, pp. 376-382
2011
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Anticancer activity and cDNA microarray studies of a (RS)-1,2,3,5- tetrahydro-4,1-benzoxazepine-3-yl]-6-chloro-9H-purine, and an acyclic (RS)-O,N-acetalic 6-chloro-7H-purine
European Journal of Medicinal Chemistry, Vol. 46, Núm. 9, pp. 3802-3809
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New (RS)-benzoxazepin-purines with antitumour activity: The chiral switch from (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1- benzoxazepin-3-yl]-9H-purine
European Journal of Medicinal Chemistry, Vol. 46, Núm. 1, pp. 249-258
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Synthesis and Anticancer Activity of the (R,S)-Benzofused 1,5-Oxathiepine Moiety Tethered to Purines through Alkylidenoxy Linkers
ChemMedChem, Vol. 6, Núm. 10, pp. 1854-1859
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Synthesis and anticancer activity of (RS)-9-(2,3-dihydro-1,4- benzoxaheteroin-2-ylmethyl)-9H-purines
European Journal of Medicinal Chemistry, Vol. 46, Núm. 9, pp. 3795-3801
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The chemotherapeutic drug 5-fluorouracil promotes PKR-mediated apoptosis in a p53- independent manner in colon and breast cancer cells
PLoS ONE, Vol. 6, Núm. 8
2009
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Acyclonucleosides, modified seco-nucleosides, and salicyl- or catechol-derived acyclic 5-fluorouracil O,N-acetals: Antiproliferative activities, cellular differentiation and apoptosis
Current Medicinal Chemistry, Vol. 16, Núm. 9, pp. 1166-1183
2008
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Anticancer activity of (1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-pyrimidines and -purines against the MCF-7 cell line: Preliminary cDNA microarray studies
Bioorganic and Medicinal Chemistry Letters, Vol. 18, Núm. 4, pp. 1457-1460
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Regiospecific microwave-assisted synthesis and cytotoxic activity against human breast cancer cells of (RS)-6-substituted-7- or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or -9H-purines
European Journal of Medicinal Chemistry, Vol. 43, Núm. 8, pp. 1742-1748
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Synthesis and anticancer activity of (R,S)-9-(2,3-dihydro-1,4-benzoxathiin- 3-ylmethyl)-9H-purines
ChemMedChem, Vol. 3, Núm. 1, pp. 127-135
2007
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5-fluorouracil derivatives induce differentiation mediated by tubulin and HLA class I modulation
Medicinal Chemistry, Vol. 3, Núm. 3, pp. 233-239