QUÍMICA FARMACÉUTICA Y ORGÁNICA
DEPARTAMENTO
DARÍO
ACUÑA CASTROVIEJO
Investigador desde null
Publicacións nas que colabora con DARÍO ACUÑA CASTROVIEJO (18)
2016
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Synthesis of oxadiazoline and quinazolinone derivatives and their biological evaluation as nitric oxide synthase inhibitors
Medicinal Chemistry Research, Vol. 25, Núm. 6, pp. 1260-1273
2013
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Synthesis and biological evaluation of 4,5-dihydro-1H-pyrazole derivatives as potential nNOS/iNOS selective inhibitors. Part 2: Influence of diverse substituents in both the phenyl moiety and the acyl group
Bioorganic and Medicinal Chemistry, Vol. 21, Núm. 14, pp. 4132-4142
2012
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1,3,4-Thiadiazole derivatives as selective inhibitors of iNOS versus nNOS: Synthesis and structure-activity dependence
European Journal of Medicinal Chemistry, Vol. 50, pp. 129-139
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Melatonin synthetic analogs as nitric oxide synthase inhibitors
Mini-Reviews in Medicinal Chemistry, Vol. 12, Núm. 7, pp. 600-617
2011
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Protective effects of synthetic kynurenines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice
Brain Research Bulletin, Vol. 85, Núm. 3-4, pp. 133-140
2009
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Melatonin and its brain metabolite N1-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in Parkinsonian mice
Journal of Neuroscience Research, Vol. 87, Núm. 13, pp. 3002-3010
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Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors
European Journal of Medicinal Chemistry, Vol. 44, Núm. 6, pp. 2655-2666
2008
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Pyrazoles and pyrazolines as neural and inducible nitric oxide synthase (nNOS and iNOS) potential inhibitors (III)
European Journal of Medicinal Chemistry, Vol. 43, Núm. 11, pp. 2579-2591
2007
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Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture
Journal of Pineal Research, Vol. 43, Núm. 2, pp. 195-205
2006
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Inhibition of neuronal nitric oxide synthase activity by N 1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin
Journal of Neurochemistry, Vol. 98, Núm. 6, pp. 2023-2033
2005
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Kynurenamines as neural nitric oxide synthase inhibitors
Journal of Medicinal Chemistry, Vol. 48, Núm. 26, pp. 8174-8181
2004
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4,5-Dihydro-1H-pyrazole derivatives with inhibitory nNOS activity in rat brain: Synthesis and structure - Activity relationships
Journal of Medicinal Chemistry, Vol. 47, Núm. 23, pp. 5641-5650
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Effects of some synthetic kynurenines on brain amino acids and nitric oxide after pentylenetetrazole administration to rats
Journal of Pineal Research, Vol. 36, Núm. 4, pp. 267-277
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Synthesis and iNOS/nNOS inhibitory activities of new benzoylpyrazoline derivatives
Tetrahedron, Vol. 60, Núm. 18, pp. 4051-4069
2002
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Inhibition of nNOS activity in rat brain by synthetic kynurenines: Structure - Activity dependence
Journal of Medicinal Chemistry, Vol. 45, Núm. 2, pp. 263-274
2000
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Structure-related inhibition of calmodulin-dependent neuronal nitric-oxide synthase activity by melatonin and synthetic kynurenines
Molecular Pharmacology, Vol. 58, Núm. 5, pp. 967-975
1998
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Modification of nitric oxide synthase activity and neuronal response in rat striatum by melatonin and kynurenine derivatives
Journal of Neuroendocrinology, Vol. 10, Núm. 4, pp. 297-302
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Modulation of rat striatal glutamatergic response in search for new neuroprotective agents: Evaluation of melatonin and some kynurenine derivatives
Brain Research Bulletin, Vol. 45, Núm. 5, pp. 525-530