Publikationen in Zusammenarbeit mit Forschern von KU Leuven (28)

2022

  1. Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells

    Molecular Cell, Vol. 82, Núm. 23, pp. 4537-4547.e7

2021

  1. An effective polymeric nanocarrier that allows for active targeting and selective drug delivery in cell coculture systems

    Nanoscale, Vol. 13, Núm. 6, pp. 3500-3511

2018

  1. 2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition

    European Journal of Medicinal Chemistry, Vol. 143, pp. 683-698

2014

  1. Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents

    Bioorganic and Medicinal Chemistry, Vol. 22, Núm. 18, pp. 5097-5109

2013

  1. Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione

    European Journal of Medicinal Chemistry, Vol. 63, pp. 544-557

  2. Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[ b ]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents

    Journal of Medicinal Chemistry, Vol. 56, Núm. 22, pp. 9296-9309

2012

  1. Design, synthesis and biological evaluation of hybrid molecules containing conjugated styryl ketone and α-bromoacryloyl moieties

    Letters in Drug Design and Discovery, Vol. 9, Núm. 2, pp. 140-152

2011

  1. One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5- (3′,4′,5′-trimethoxybenzoyl)thiazole: A unique, highly active antimicrotubule agent

    European Journal of Medicinal Chemistry, Vol. 46, Núm. 12, pp. 6015-6024

  2. Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2-(3',4',5'-Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis

    ChemMedChem, Vol. 6, Núm. 10, pp. 1841-1853

  3. Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero) arylethynyl thiophene derivatives

    Bioorganic and Medicinal Chemistry Letters

2010

  1. Substituted 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b] thiophene derivatives as potent tubulin polymerization inhibitors

    Bioorganic and Medicinal Chemistry, Vol. 18, Núm. 14, pp. 5114-5122

  2. Symmetrical α-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation

    Bioorganic and Medicinal Chemistry Letters, Vol. 20, Núm. 9, pp. 2733-2739

  3. Synthesis and cellular pharmacology studies of a series of 2-amino-3-aroyl-4-substituted thiophene derivatives

    Medicinal Chemistry, Vol. 6, Núm. 6, pp. 329-343

2009

  1. 2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization

    Journal of Medicinal Chemistry, Vol. 52, Núm. 17, pp. 5551-5555

  2. Design, synthesis and structure-activity relationship of 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization

    Bioorganic and Medicinal Chemistry, Vol. 17, Núm. 19, pp. 6862-6871

  3. Discovery of 8-methoxypyrazino[1,2-a]indole as a new potent antiproliferative agent against human leukemia K562 cells. A structure-activity relationship study

    Letters in Drug Design and Discovery, Vol. 6, Núm. 4, pp. 298-303

  4. Hybrid α-bromoacryloylamido chalcones. Design, synthesis and biological evaluation

    Bioorganic and Medicinal Chemistry Letters, Vol. 19, Núm. 7, pp. 2022-2028

2008

  1. Design, synthesis, and biological evaluation of thiophene analogues of chalcones

    Bioorganic and Medicinal Chemistry, Vol. 16, Núm. 10, pp. 5367-5376

  2. Synthesis and biological evaluation of 1-methyl-2-(3′,4′, 5′-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors

    Journal of Medicinal Chemistry, Vol. 51, Núm. 5, pp. 1464-1468

  3. Synthesis and biological evaluation of 2-(3′,4′,5′-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization

    Bioorganic and Medicinal Chemistry, Vol. 16, Núm. 18, pp. 8419-8426